10.18453/rosdok_id00004576 Müller-Eigner, Annika Annika Müller-Eigner http://d-nb.info/gnd/1328159906 Universität Rostock 2023 500 Natural sciences 570 Life science 2023 en https://purl.uni-rostock.de/rosdok/id00004576 urn:nbn:de:gbv:28-rosdok_id00004576-2 In this thesis, the impact of sodium butyrate (SB) on mitochondrial and metabolic function and lifespan was investigated. SB treatment showed a rapid and transient increase in oxygen consumption in fly heads. Mass spectrometry analysis revealed incorporation of labeled SB into mitochondrial pathway metabolites. An SB-independent way for mitochondrial activation was assessed in this work. The mitochondrial membrane potential of C. elegans was increased, using a light-activated proton pump, resulting in an extended median lifespan, even if the intervention took part in mid- or late-staged worms.