10.18453/rosdok_id00004764 Hartner, Elena Rosa Elena Rosa Hartner http://d-nb.info/gnd/1364005689 https://orcid.org/0000-0002-6798-2403 Universität Rostock 2023 500 Natural sciences 540 Chemistry & allied sciences 550 Earth sciences 2023 en https://purl.uni-rostock.de/rosdok/id00004764 urn:nbn:de:gbv:28-rosdok_id00004764-5 This dissertation presents an analytical scenario for a comprehensive chemical analysis of organic aerosols by combining different instrumentation based on electron ionization and time-of-flight mass spectrometry (TOFMS). Two-dimensional gas chromatography TOFMS was performed to provide in-depth molecular information on these complex organic mixtures. This thesis highlights the importance of a complementary experimental and analytical approach and makes a valuable contribution towards understanding the relationship between the toxicological effects and chemical composition of aerosols.