10.18453/rosdok_id00004765 Schwalb, Lukas Felix Lukas Felix Schwalb http://d-nb.info/gnd/1364044773 Universität Rostock 2024 500 Natural sciences 540 Chemistry & allied sciences 2024 en https://purl.uni-rostock.de/rosdok/id00004765 urn:nbn:de:gbv:28-rosdok_id00004765-1 The comprehensive chemical description of active pharmaceutical ingredients (APIs) of complex drugs is an analytical challenge. This also applies to bituminosulfonates. This study addresses the in-depth chemical description of the APIs and their characteristic manufacturing process via applying and adapting comprehensive two-dimensional gas chromatography coupled with high-resolution mass spectrometry (GCxGC HR-MS). As a result, it describes comprehensively and in detail the chemical identity of the bituminosulfonates and their manufacturing process at the molecular level.