mycoreobjectrosdok_disshab_0000003285rosdok_disshab_0000003285rosdokdisshabrosdok_derivate_00002250962025-07-18T12:02:29.141Z2025-07-18T11:38:18.682ZMCRJANITOReditorFGpublished1rosdok_derivate_0000225096truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000048741931303371Oau2025-07-182025-07-18T11:51:36ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.10 [SCM: "f6c168af690edb7cb65ef34e4a2bf7f8714c5d38" "v2.10" "2024-03-28T14:43:08+0100"] with mode 'DEFAULT'.DissertationHochschulschriftEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesThe respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was optimized for collecting flavored aerosols. Based on the results, a tiered testing approach is advised using submerged and Air-Liquid Interface cell models. Further, standardized testing guidelines for flavoring compounds in emerging ANDS are needed for comprehensive safety assessments.SelinaRinaldi1992 -VerfasserInaut1371837376RalfZimmermann1963 -AkademischeR BetreuerIndgs143922025University of Rostock, Institute of ChemistryTanjaSchwerdtle1975 -AkademischeR BetreuerIndgs1284513350000-0002-4873-7488Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg2147083-2Universität Rostock. Mathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00004874urn:nbn:de:gbv:28-rosdok_id00004874-810.18453/rosdok_id00004874500 Naturwissenschaften540 Chemie570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2025Universität RostockRostockmonographic202520252025Universitätsbibliothek RostockRostock2025Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004874Der Volltext der Zeitschriftenartikel ist nur in der Druckausgabe vorhandenRalf Zimmermann (University of Rostock, Institute of Chemistry) ; Tanja Schwerdtle (Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry)[{"name":"Zimmermann, Ralf","affil":"University of Rostock, Institute of Chemistry"},{"name":"Schwerdtle, Tanja","affil":"Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry"}]Dissertation, Universität Rostock, 2025, Kumulative Dissertationvorgelegt von Selina RinaldiZimmermann, RalfUniversity of Rostock, Institute of ChemistrySchwerdtle, TanjaMax Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistrydoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:500SDNB:500500 Naturwissenschaften500 Natural sciencesSDNB:540SDNB:540540 Chemie540 Chemistry & allied sciencesSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesgnd:1371837376gnd:143922025gnd:128451335orcid:0000-0002-4873-7488gnd:38329-6gnd:2147083-2gnd:1371837376gnd:143922025gnd:128451335orcid:0000-0002-4873-7488gnd:38329-6gnd:2147083-2rosdok_disshab_0000003285-d2335771e52gnd:1371837376Selina RinaldiSelina Rinaldirosdok_disshab_0000003285-d2335771e66gnd:143922025Ralf ZimmermannRalf Zimmermannrosdok_disshab_0000003285-d2335771e81gnd:128451335orcid:0000-0002-4873-7488Tanja SchwerdtleTanja Schwerdtlerosdok_disshab_0000003285-d2335771e98gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003285-d2335771e112gnd:2147083-2Universität Rostock. Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätSelina RinaldiRalf ZimmermannTanja SchwerdtleUniversität RostockUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätSelina RinaldiRalf ZimmermannTanja SchwerdtleUniversität RostockUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätSelina RinaldiRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00004874urn:nbn:de:gbv:28-rosdok_id00004874-810.18453/rosdok_id00004874The respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was optimized for collecting flavored aerosols. Based on the results, a tiered testing approach is advised using submerged and Air-Liquid Interface cell models. Further, standardized testing guidelines for flavoring compounds in emerging ANDS are needed for comprehensive safety assessments.20252025Der Volltext der Zeitschriftenartikel ist nur in der Druckausgabe vorhandenRalf Zimmermann (University of Rostock, Institute of Chemistry) ; Tanja Schwerdtle (Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry)[{"name":"Zimmermann, Ralf","affil":"University of Rostock, Institute of Chemistry"},{"name":"Schwerdtle, Tanja","affil":"Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry"}]Dissertation, Universität Rostock, 2025, Kumulative Dissertationvorgelegt von Selina Rinaldiepub.dissertation1 Rinaldi_Dissertation_2025.pdf 3922426 c2eef44b6d91f92c42183753f6bd5f5a rosdok/id000048741931303371Oau2025-07-182025-07-18T11:51:36ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.10 [SCM: "f6c168af690edb7cb65ef34e4a2bf7f8714c5d38" "v2.10" "2024-03-28T14:43:08+0100"] with mode 'DEFAULT'.DissertationHochschulschriftEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesThe respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was optimized for collecting flavored aerosols. Based on the results, a tiered testing approach is advised using submerged and Air-Liquid Interface cell models. Further, standardized testing guidelines for flavoring compounds in emerging ANDS are needed for comprehensive safety assessments.SelinaRinaldi1992 -VerfasserInaut1371837376RalfZimmermann1963 -AkademischeR BetreuerIndgs143922025University of Rostock, Institute of ChemistryTanjaSchwerdtle1975 -AkademischeR BetreuerIndgs1284513350000-0002-4873-7488Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg2147083-2Universität Rostock. Mathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00004874urn:nbn:de:gbv:28-rosdok_id00004874-810.18453/rosdok_id00004874500 Naturwissenschaften540 Chemie570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2025Universität RostockRostockmonographic202520252025Universitätsbibliothek RostockRostock2025Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004874Der Volltext der Zeitschriftenartikel ist nur in der Druckausgabe vorhandenRalf Zimmermann (University of Rostock, Institute of Chemistry) ; Tanja Schwerdtle (Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry)[{"name":"Zimmermann, Ralf","affil":"University of Rostock, Institute of Chemistry"},{"name":"Schwerdtle, Tanja","affil":"Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry"}]Dissertation, Universität Rostock, 2025, Kumulative Dissertationvorgelegt von Selina Rinaldi Zimmermann, Ralf University of Rostock, Institute of Chemistry Schwerdtle, Tanja Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry 2025-07-18T11:38:18.682Z 2025-07-18T12:02:29.141Z 2025-07-28T12:02:29.150Z editorFG {"identifier":"rosdok/id00004874","type":"local_id","additional":"","service":"MCRLocalID","created":"2025-07-18T11:38:19.042Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00004874-8","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2025-07-18T11:38:19.121Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00004874","type":"purl","additional":"","service":"RosDokPURL","created":"2025-07-18T11:38:19.129Z","registrationStarted":"2025-07-18T12:02:27.734Z"} {"identifier":"10.18453/rosdok_id00004874","type":"doi","additional":"","service":"RosDokDOI","created":"2025-07-18T11:38:19.136Z","registrationStarted":"2025-07-18T12:02:27.474Z","registered":"2025-07-18T12:02:29.138Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003285/rosdok_derivate_0000225096/Rinaldi_Dissertation_2025.pdfEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesgnd:1371837376gnd:143922025gnd:128451335orcid:0000-0002-4873-7488gnd:38329-6gnd:2147083-2gnd:1371837376gnd:143922025gnd:128451335orcid:0000-0002-4873-7488gnd:38329-6gnd:2147083-2rosdok_disshab_0000003285-d2335771e52gnd:1371837376Selina RinaldiSelina Rinaldirosdok_disshab_0000003285-d2335771e66gnd:143922025Ralf ZimmermannRalf Zimmermannrosdok_disshab_0000003285-d2335771e81gnd:128451335orcid:0000-0002-4873-7488Tanja SchwerdtleTanja Schwerdtlerosdok_disshab_0000003285-d2335771e98gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003285-d2335771e112gnd:2147083-2Universität Rostock. Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätSelina RinaldiRalf ZimmermannTanja SchwerdtleUniversität RostockUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätSelina RinaldiRalf ZimmermannTanja SchwerdtleUniversität RostockUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätSelina RinaldiRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00004874urn:nbn:de:gbv:28-rosdok_id00004874-810.18453/rosdok_id00004874The respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was optimized for collecting flavored aerosols. Based on the results, a tiered testing approach is advised using submerged and Air-Liquid Interface cell models. Further, standardized testing guidelines for flavoring compounds in emerging ANDS are needed for comprehensive safety assessments.20252025Der Volltext der Zeitschriftenartikel ist nur in der Druckausgabe vorhandenRalf Zimmermann (University of Rostock, Institute of Chemistry) ; Tanja Schwerdtle (Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry)[{"name":"Zimmermann, Ralf","affil":"University of Rostock, Institute of Chemistry"},{"name":"Schwerdtle, Tanja","affil":"Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry"}]Dissertation, Universität Rostock, 2025, Kumulative Dissertationvorgelegt von Selina Rinaldi[xslt]Saxonrosdok/id00004874https://purl.uni-rostock.de/rosdok/id00004874193130337110.18453/rosdok_id00004874urn:nbn:de:gbv:28-rosdok_id00004874-8Selina RinaldiRinaldi SelinaEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesDissertationdoctoral thesisUniversität Rostock, 2025The respiratory and local health effects of flavors in alternative nicotine delivery systems (ANDS) are not well understood. This dissertation aimed to develop an in vitro risk assessment strategy for ANDS flavors and identify oral nicotine pouch (ONP) ingredients. Further, the impinger method was…Selina RinaldiEvaluating in vitro toxicity of flavors in alternative nicotine delivery systems utilizing different in vitro testing strategiesUniversitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004874SelinaRinaldi1992 -VerfasserInaut1371837376RalfZimmermann1963 -AkademischeR BetreuerIndgs143922025University of Rostock, Institute of ChemistryTanjaSchwerdtle1975 -AkademischeR BetreuerIndgs1284513350000-0002-4873-7488Max Rubner-Institut and University of Potsdam, Institute of Nutritional Science, Department of Food Chemistry38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg2147083-2Universität Rostock. Mathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00004874[urn]urn:nbn:de:gbv:28-rosdok_id00004874-8[doi]10.18453/rosdok_id00004874open_access20252025epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:500SDNB:540SDNB:570institution:unirostock.mnfstate:published