Generation and characterization of ultrafine particles in laboratory studies and their mass deposition at the air-liquid interface

10.18453/rosdok_id00004910 Das, Anusmita Anusmita Das http://d-nb.info/gnd/137587053X https://orcid.org/0009-0002-2217-7555 Generation and characterization of ultrafine particles in laboratory studies and their mass deposition at the air-liquid interface Universität Rostock 2025 500 Natural sciences 540 Chemistry & allied sciences 2025 en https://purl.uni-rostock.de/rosdok/id00004910 urn:nbn:de:gbv:28-rosdok_id00004910-8 Ultrafine particles (UFPs, ≤100 nm) contribute to air pollution's health impacts, but their toxicity drivers are unclear. This study generated soot UFPs with similar cores but varying chemical loads (e.g., PAHs) and tested them on A549 cells in ALI systems. Higher PAH content increased xenobiotic metabolism, showing chemical composition's role. Soot and copper UFPs, matched physically, revealed higher-than-predicted mass deposition in ALI systems, highlighting model limitations. The method enables precise UFP property control, advancing reproducible toxicity assessments.