10.18453/rosdok_id00005031 Tang, Guanglin Guanglin Tang http://d-nb.info/gnd/1384191208 https://orcid.org/0000-0001-5952-8182 Universität Rostock 2023 570 Life science 610 Medical sciences Medicine 2023 en https://purl.uni-rostock.de/rosdok/id00005031 urn:nbn:de:gbv:28-rosdok_id00005031-6 There are few studies that define which methods are appropriate to measure the severity of suffering in animals. In the first study, we showed that corticosterone elevation is an important parameter for the assessment of distress in mice. In the second study, we analyzed the diagnostic value of a distress score, burrowing activity and body weight change in animal models of liver fibrosis. In the third study, the power of single and multiple parameters to determine an early humane endpoint was analyzed.