mycoreobjectrosdok_disshab_0000003390rosdok_disshab_0000003390rosdokdisshabrosdok_derivate_00002259582026-01-28T15:19:28.840Z2026-01-28T14:30:24.972ZMCRJANITOReditorFGpublished1rosdok_derivate_0000225958truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000050841950519996Oau2026-01-282026-01-28T14:44:46ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.10 [SCM: "f6c168af690edb7cb65ef34e4a2bf7f8714c5d38" "v2.10" "2024-03-28T14:43:08+0100"] with mode 'DEFAULT'.DissertationHochschulschriftAradiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesThe herein-developed bioinformatics workflow aims to improve the interpretability of results from a multi-omics integration. Extraction of 86 image features from the CT image series describing tumor characteristics is followed by differential expression/methylation analysis. Regulation of signaling and cellular response to organic substance were reflected in CT image phenotypes. Hypomethylation showed a distinct shift in tumor texture. The described approach is generalizable to other cancer entities or non-malignant diseases to broaden the interpretability of future radiogenomics studies.Nicolas LucaSpath1996 -VerfasserInaut13882336140000-0002-2189-1389GeorgFüllen1967 -AkademischeR BetreuerIndgs1406260850000-0002-4994-9829Marc-AndréWeber1973 -AkademischeR BetreuerIndgs1423730440000-0003-3918-8066Institute for Diagnostic and Interventional Radiology, University RostockJan-BerndHövenerAkademischeR BetreuerIndgs1370437400000-0001-7255-725238329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005084urn:nbn:de:gbv:28-rosdok_id00005084-910.18453/rosdok_id00005084004 Informatik500 Naturwissenschaften610 Medizin, GesundheitUniversitätsmedizinCC BY-SA 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (110 Seiten)2024Universität RostockRostockmonographic202420242026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005084Georg Fuellen (Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock) ; Marc-André Weber (Institute for Diagnostic and Interventional Radiology, University Rostock) ; Jan Hövener (Molecular Imaging North Competence Center, University Kiel)[{"name":"Fuellen, Georg","affil":"Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock"},{"name":"Weber, Marc-André","affil":"Institute for Diagnostic and Interventional Radiology, University Rostock"},{"name":"Hövener, Jan","affil":"Molecular Imaging North Competence Center, University Kiel"}]Dissertation, Universität Rostock, 2024Computer tomographyvorgelegt von Nicolas Luca SpathFuellen, GeorgInstitute for Biostatistics and Informatics in Medicine and Ageing Research, University RostockWeber, Marc-AndréInstitute for Diagnostic and Interventional Radiology, University RostockHövener, JanMolecular Imaging North Competence Center, University Kieldoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:004SDNB:004004 Informatik004 Data processing Computer sciencesSDNB:500SDNB:500500 Naturwissenschaften500 Natural sciencesSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.cclicenselicenseinfo:work.cclicenseCC-LizenzCC-licenselicenseinfo:work.cclicense.cc-by-salicenseinfo:work.cclicense.cc-by-saCC BY-SACC BY-SAlicenseinfo:work.cclicense.cc-by-sa.v40licenseinfo:work.cclicense.cc-by-sa.v40CC BY-SA 4.0CC BY-SA 4.0/creativecommons/l/by-sa/4.0/88x31.png[DE-28]Namensnennung - Weitergabe unter gleichen Bedingungen 4.0 International$cCC BY-SA 4.0$gCreative Commons$uhttps://creativecommons.org/licenses/by-sa/4.0/https://creativecommons.org/licenses/by-sa/4.0/https://creativecommons.org/licenses/by-sa/4.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengAradiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesA radiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesgnd:1388233614orcid:0000-0002-2189-1389gnd:140626085orcid:0000-0002-4994-9829gnd:142373044orcid:0000-0003-3918-8066gnd:137043740orcid:0000-0001-7255-7252gnd:38329-6gnd:1029510660gnd:1388233614orcid:0000-0002-2189-1389gnd:140626085orcid:0000-0002-4994-9829gnd:142373044orcid:0000-0003-3918-8066gnd:137043740orcid:0000-0001-7255-7252gnd:38329-6gnd:1029510660rosdok_disshab_0000003390-d199880e53gnd:1388233614orcid:0000-0002-2189-1389Nicolas Luca SpathNicolas Luca Spathrosdok_disshab_0000003390-d199880e69gnd:140626085orcid:0000-0002-4994-9829Georg FüllenGeorg Füllenrosdok_disshab_0000003390-d199880e85gnd:142373044orcid:0000-0003-3918-8066Marc-André WeberMarc-André Weberrosdok_disshab_0000003390-d199880e102gnd:137043740orcid:0000-0001-7255-7252Jan-Bernd HövenerJan-Bernd Hövenerrosdok_disshab_0000003390-d199880e117gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003390-d199880e130gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockNicolas Luca SpathGeorg FüllenMarc-André WeberJan-Bernd HövenerUniversität RostockUniversitätsmedizin RostockNicolas Luca SpathGeorg FüllenMarc-André WeberJan-Bernd HövenerUniversität RostockUniversitätsmedizin RostockNicolas Luca SpathRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005084urn:nbn:de:gbv:28-rosdok_id00005084-910.18453/rosdok_id00005084The herein-developed bioinformatics workflow aims to improve the interpretability of results from a multi-omics integration. Extraction of 86 image features from the CT image series describing tumor characteristics is followed by differential expression/methylation analysis. Regulation of signaling and cellular response to organic substance were reflected in CT image phenotypes. Hypomethylation showed a distinct shift in tumor texture. The described approach is generalizable to other cancer entities or non-malignant diseases to broaden the interpretability of future radiogenomics studies.20242024Georg Fuellen (Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock) ; Marc-André Weber (Institute for Diagnostic and Interventional Radiology, University Rostock) ; Jan Hövener (Molecular Imaging North Competence Center, University Kiel)[{"name":"Fuellen, Georg","affil":"Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock"},{"name":"Weber, Marc-André","affil":"Institute for Diagnostic and Interventional Radiology, University Rostock"},{"name":"Hövener, Jan","affil":"Molecular Imaging North Competence Center, University Kiel"}]Dissertation, Universität Rostock, 2024Computer tomographyvorgelegt von Nicolas Luca Spathepub.dissertation1 Spath_Dissertation_2026.pdf 8273483 03da6d60fd87ecdfe33554357c15d466 rosdok/id000050841950519996Oau2026-01-282026-01-28T14:44:46ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.10 [SCM: "f6c168af690edb7cb65ef34e4a2bf7f8714c5d38" "v2.10" "2024-03-28T14:43:08+0100"] with mode 'DEFAULT'.DissertationHochschulschriftAradiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesThe herein-developed bioinformatics workflow aims to improve the interpretability of results from a multi-omics integration. Extraction of 86 image features from the CT image series describing tumor characteristics is followed by differential expression/methylation analysis. Regulation of signaling and cellular response to organic substance were reflected in CT image phenotypes. Hypomethylation showed a distinct shift in tumor texture. The described approach is generalizable to other cancer entities or non-malignant diseases to broaden the interpretability of future radiogenomics studies.Nicolas LucaSpath1996 -VerfasserInaut13882336140000-0002-2189-1389GeorgFüllen1967 -AkademischeR BetreuerIndgs1406260850000-0002-4994-9829Marc-AndréWeber1973 -AkademischeR BetreuerIndgs1423730440000-0003-3918-8066Institute for Diagnostic and Interventional Radiology, University RostockJan-BerndHövenerAkademischeR BetreuerIndgs1370437400000-0001-7255-725238329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005084urn:nbn:de:gbv:28-rosdok_id00005084-910.18453/rosdok_id00005084004 Informatik500 Naturwissenschaften610 Medizin, GesundheitUniversitätsmedizinCC BY-SA 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (110 Seiten)2024Universität RostockRostockmonographic202420242026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005084Georg Fuellen (Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock) ; Marc-André Weber (Institute for Diagnostic and Interventional Radiology, University Rostock) ; Jan Hövener (Molecular Imaging North Competence Center, University Kiel)[{"name":"Fuellen, Georg","affil":"Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock"},{"name":"Weber, Marc-André","affil":"Institute for Diagnostic and Interventional Radiology, University Rostock"},{"name":"Hövener, Jan","affil":"Molecular Imaging North Competence Center, University Kiel"}]Dissertation, Universität Rostock, 2024Computer tomographyvorgelegt von Nicolas Luca Spath Fuellen, Georg Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock Weber, Marc-André Institute for Diagnostic and Interventional Radiology, University Rostock Hövener, Jan Molecular Imaging North Competence Center, University Kiel 2026-01-28T14:30:24.972Z 2026-01-28T15:19:28.840Z 2026-02-07T15:19:28.849Z editorFG {"identifier":"rosdok/id00005084","type":"local_id","additional":"","service":"MCRLocalID","created":"2026-01-28T14:30:26.774Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00005084-9","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2026-01-28T14:30:26.841Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00005084","type":"purl","additional":"","service":"RosDokPURL","created":"2026-01-28T14:30:26.852Z","registrationStarted":"2026-01-28T15:19:27.318Z"} {"identifier":"10.18453/rosdok_id00005084","type":"doi","additional":"","service":"RosDokDOI","created":"2026-01-28T14:30:26.863Z","registrationStarted":"2026-01-28T15:19:26.663Z","registered":"2026-01-28T15:19:28.834Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003390/rosdok_derivate_0000225958/Spath_Dissertation_2026.pdfAradiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesA radiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesgnd:1388233614orcid:0000-0002-2189-1389gnd:140626085orcid:0000-0002-4994-9829gnd:142373044orcid:0000-0003-3918-8066gnd:137043740orcid:0000-0001-7255-7252gnd:38329-6gnd:1029510660gnd:1388233614orcid:0000-0002-2189-1389gnd:140626085orcid:0000-0002-4994-9829gnd:142373044orcid:0000-0003-3918-8066gnd:137043740orcid:0000-0001-7255-7252gnd:38329-6gnd:1029510660rosdok_disshab_0000003390-d199880e53gnd:1388233614orcid:0000-0002-2189-1389Nicolas Luca SpathNicolas Luca Spathrosdok_disshab_0000003390-d199880e69gnd:140626085orcid:0000-0002-4994-9829Georg FüllenGeorg Füllenrosdok_disshab_0000003390-d199880e85gnd:142373044orcid:0000-0003-3918-8066Marc-André WeberMarc-André Weberrosdok_disshab_0000003390-d199880e102gnd:137043740orcid:0000-0001-7255-7252Jan-Bernd HövenerJan-Bernd Hövenerrosdok_disshab_0000003390-d199880e117gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003390-d199880e130gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockNicolas Luca SpathGeorg FüllenMarc-André WeberJan-Bernd HövenerUniversität RostockUniversitätsmedizin RostockNicolas Luca SpathGeorg FüllenMarc-André WeberJan-Bernd HövenerUniversität RostockUniversitätsmedizin RostockNicolas Luca SpathRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005084urn:nbn:de:gbv:28-rosdok_id00005084-910.18453/rosdok_id00005084The herein-developed bioinformatics workflow aims to improve the interpretability of results from a multi-omics integration. Extraction of 86 image features from the CT image series describing tumor characteristics is followed by differential expression/methylation analysis. Regulation of signaling and cellular response to organic substance were reflected in CT image phenotypes. Hypomethylation showed a distinct shift in tumor texture. The described approach is generalizable to other cancer entities or non-malignant diseases to broaden the interpretability of future radiogenomics studies.20242024Georg Fuellen (Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock) ; Marc-André Weber (Institute for Diagnostic and Interventional Radiology, University Rostock) ; Jan Hövener (Molecular Imaging North Competence Center, University Kiel)[{"name":"Fuellen, Georg","affil":"Institute for Biostatistics and Informatics in Medicine and Ageing Research, University Rostock"},{"name":"Weber, Marc-André","affil":"Institute for Diagnostic and Interventional Radiology, University Rostock"},{"name":"Hövener, Jan","affil":"Molecular Imaging North Competence Center, University Kiel"}]Dissertation, Universität Rostock, 2024Computer tomographyvorgelegt von Nicolas Luca Spath[xslt]Saxonrosdok/id00005084https://purl.uni-rostock.de/rosdok/id00005084195051999610.18453/rosdok_id00005084urn:nbn:de:gbv:28-rosdok_id00005084-9Nicolas Luca SpathSpath Nicolas LucaA radiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesDissertationdoctoral thesisUniversität Rostock, 2024The herein-developed bioinformatics workflow aims to improve the interpretability of results from a multi-omics integration. Extraction of 86 image features from the CT image series describing tumor characteristics is followed by differential expression/methylation analysis. Regulation of signaling…Nicolas Luca SpathAradiogenomic approach in lung adenocarcinoma to unravel molecular mechanisms underlying CT imaging phenotypesComputer tomographyUniversitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005084Nicolas LucaSpath1996 -VerfasserInaut13882336140000-0002-2189-1389GeorgFüllen1967 -AkademischeR BetreuerIndgs1406260850000-0002-4994-9829Marc-AndréWeber1973 -AkademischeR BetreuerIndgs1423730440000-0003-3918-8066Institute for Diagnostic and Interventional Radiology, University RostockJan-BerndHövenerAkademischeR BetreuerIndgs1370437400000-0001-7255-725238329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00005084[urn]urn:nbn:de:gbv:28-rosdok_id00005084-9[doi]10.18453/rosdok_id00005084open_access20242024epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:004SDNB:500SDNB:610institution:unirostock.umrstate:published