mycoreobjectrosdok_disshab_0000003392rosdok_disshab_0000003392rosdokdisshabrosdok_derivate_00002259602026-01-29T16:09:36.572Z2026-01-29T14:55:18.036ZMCRJANITOReditorFGpublished1rosdok_derivate_0000225960truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000050861950629082Oau2026-01-292026-01-29T15:53:35ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.10 [SCM: "f6c168af690edb7cb65ef34e4a2bf7f8714c5d38" "v2.10" "2024-03-28T14:43:08+0100"] with mode 'DEFAULT'.DissertationHochschulschriftAccessible tools for biomolecular data analysis using large-scale knowledge graphsThe interpretation of biomolecular data is often challenging due to the heterogeneity in the structural and functional organization of biological systems. In this thesis, I created knowledge graphs of disease processes, published as interactive Disease Maps, and developed new tools for their analysis. I present (i) the Atlas of Inflammation Resolution (AIR), (ii) the two-dimensional enrichment analysis (2DEA) as a novel network-based enrichment approach, (iii) the Sarcopenia Map linking gastrointestinal diseases and sarcopenia, and (iv) the MASLD Map investigating steatotic liver diseases.MattiWelzenvan1995 -VerfasserInaut13883396410000-0002-2486-0246OlafWolkenhauer1966 -AkademischeR BetreuerIndgs1335159310000-0001-6105-2937Universität RostockDirkRepsilber1971 -AkademischeR BetreuerIndgs1065633742Örebro UniversityAnnaNiarakisAkademischeR BetreuerIndgs12398545950000-0002-9687-7426Université Paul Sabatier38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg10085032-7Universität Rostock. Fakultät für Informatik und Elektrotechnik2004 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005086urn:nbn:de:gbv:28-rosdok_id00005086-210.18453/rosdok_id00005086004 Informatik610 Medizin, GesundheitFakultät für Informatik und ElektrotechnikCC BY-NC-SA 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (xxvi, 195 Seiten)2024Mai 2024Universität RostockRostockmonographic20242026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005086Olaf Wolkenhauer (Universität Rostock) ; Dirk Repsilber (Örebro University) ; Anna Niarakis (Université Paul Sabatier)[{"name":"Wolkenhauer, Olaf","affil":"Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Örebro University"},{"name":"Niarakis, Anna","affil":"Université Paul Sabatier"}]Dissertation, Universität Rostock, 2024vorgelegt von Matti van WelzenWolkenhauer, OlafUniversität RostockRepsilber, DirkÖrebro UniversityNiarakis, AnnaUniversité Paul Sabatierdoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:004SDNB:004004 Informatik004 Data processing Computer sciencesSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. Fakultät für Informatik und ElektrotechnikFakultät für Informatik<br />und ElektrotechnikUni.Rostock.Fakultaet.IEFhttp://d-nb.info/gnd/10085032-7licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.cclicenselicenseinfo:work.cclicenseCC-LizenzCC-licenselicenseinfo:work.cclicense.cc-by-nc-salicenseinfo:work.cclicense.cc-by-nc-saCC BY-NC-SACC BY-NC-SAlicenseinfo:work.cclicense.cc-by-nc-sa.v40licenseinfo:work.cclicense.cc-by-nc-sa.v40CC BY-NC-SA 4.0CC BY-NC-SA 4.0/creativecommons/l/by-nc-sa/4.0/88x31.png[DE-28]Namensnennung - Nicht-kommerziell - Weitergabe unter gleichen Bedingungen 4.0 International$cCC BY-NC-SA 4.0$gCreative Commons$uhttps://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/4.0/https://creativecommons.org/licenses/by-nc-sa/4.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengAccessible tools for biomolecular data analysis using large-scale knowledge graphsAccessible tools for biomolecular data analysis using large-scale knowledge graphsgnd:1388339641orcid:0000-0002-2486-0246gnd:133515931orcid:0000-0001-6105-2937gnd:1065633742gnd:1239854595orcid:0000-0002-9687-7426gnd:38329-6gnd:10085032-7gnd:1388339641orcid:0000-0002-2486-0246gnd:133515931orcid:0000-0001-6105-2937gnd:1065633742gnd:1239854595orcid:0000-0002-9687-7426gnd:38329-6gnd:10085032-7rosdok_disshab_0000003392-d44559e52gnd:1388339641orcid:0000-0002-2486-0246Matti Welzen vanMatti Welzen vanrosdok_disshab_0000003392-d44559e70gnd:133515931orcid:0000-0001-6105-2937Olaf WolkenhauerOlaf Wolkenhauerrosdok_disshab_0000003392-d44559e87gnd:1065633742Dirk RepsilberDirk Repsilberrosdok_disshab_0000003392-d44559e102gnd:1239854595orcid:0000-0002-9687-7426Anna NiarakisAnna Niarakisrosdok_disshab_0000003392-d44559e118gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003392-d44559e131gnd:10085032-7Universität Rostock. Fakultät für Informatik und ElektrotechnikUniversität Rostock. Fakultät für Informatik und ElektrotechnikMatti Welzen vanOlaf WolkenhauerDirk RepsilberAnna NiarakisUniversität RostockUniversität Rostock. Fakultät für Informatik und ElektrotechnikMatti Welzen vanOlaf WolkenhauerDirk RepsilberAnna NiarakisUniversität RostockUniversität Rostock. Fakultät für Informatik und ElektrotechnikMatti Welzen vanRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005086urn:nbn:de:gbv:28-rosdok_id00005086-210.18453/rosdok_id00005086The interpretation of biomolecular data is often challenging due to the heterogeneity in the structural and functional organization of biological systems. In this thesis, I created knowledge graphs of disease processes, published as interactive Disease Maps, and developed new tools for their analysis. I present (i) the Atlas of Inflammation Resolution (AIR), (ii) the two-dimensional enrichment analysis (2DEA) as a novel network-based enrichment approach, (iii) the Sarcopenia Map linking gastrointestinal diseases and sarcopenia, and (iv) the MASLD Map investigating steatotic liver diseases.20242024Olaf Wolkenhauer (Universität Rostock) ; Dirk Repsilber (Örebro University) ; Anna Niarakis (Université Paul Sabatier)[{"name":"Wolkenhauer, Olaf","affil":"Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Örebro University"},{"name":"Niarakis, Anna","affil":"Université Paul Sabatier"}]Dissertation, Universität Rostock, 2024vorgelegt von Matti van Welzenepub.dissertation1 vanWelzen_Dissertation_2026.pdf 29165500 0ffc937b940743cc5f8bcfef6ef4845f rosdok/id000050861950629082Oau2026-01-292026-01-29T15:53:35ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.10 [SCM: "f6c168af690edb7cb65ef34e4a2bf7f8714c5d38" "v2.10" "2024-03-28T14:43:08+0100"] with mode 'DEFAULT'.DissertationHochschulschriftAccessible tools for biomolecular data analysis using large-scale knowledge graphsThe interpretation of biomolecular data is often challenging due to the heterogeneity in the structural and functional organization of biological systems. In this thesis, I created knowledge graphs of disease processes, published as interactive Disease Maps, and developed new tools for their analysis. I present (i) the Atlas of Inflammation Resolution (AIR), (ii) the two-dimensional enrichment analysis (2DEA) as a novel network-based enrichment approach, (iii) the Sarcopenia Map linking gastrointestinal diseases and sarcopenia, and (iv) the MASLD Map investigating steatotic liver diseases.MattiWelzenvan1995 -VerfasserInaut13883396410000-0002-2486-0246OlafWolkenhauer1966 -AkademischeR BetreuerIndgs1335159310000-0001-6105-2937Universität RostockDirkRepsilber1971 -AkademischeR BetreuerIndgs1065633742Örebro UniversityAnnaNiarakisAkademischeR BetreuerIndgs12398545950000-0002-9687-7426Université Paul Sabatier38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg10085032-7Universität Rostock. Fakultät für Informatik und Elektrotechnik2004 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005086urn:nbn:de:gbv:28-rosdok_id00005086-210.18453/rosdok_id00005086004 Informatik610 Medizin, GesundheitFakultät für Informatik und ElektrotechnikCC BY-NC-SA 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (xxvi, 195 Seiten)2024Mai 2024Universität RostockRostockmonographic20242026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005086Olaf Wolkenhauer (Universität Rostock) ; Dirk Repsilber (Örebro University) ; Anna Niarakis (Université Paul Sabatier)[{"name":"Wolkenhauer, Olaf","affil":"Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Örebro University"},{"name":"Niarakis, Anna","affil":"Université Paul Sabatier"}]Dissertation, Universität Rostock, 2024vorgelegt von Matti van Welzen Wolkenhauer, Olaf Universität Rostock Repsilber, Dirk Örebro University Niarakis, Anna Université Paul Sabatier 2026-01-29T14:55:18.036Z 2026-01-29T16:09:36.572Z 2026-02-08T16:09:36.585Z editorFG {"identifier":"rosdok/id00005086","type":"local_id","additional":"","service":"MCRLocalID","created":"2026-01-29T14:55:19.771Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00005086-2","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2026-01-29T14:55:19.826Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00005086","type":"purl","additional":"","service":"RosDokPURL","created":"2026-01-29T14:55:19.836Z","registrationStarted":"2026-01-29T16:09:35.130Z"} {"identifier":"10.18453/rosdok_id00005086","type":"doi","additional":"","service":"RosDokDOI","created":"2026-01-29T14:55:19.845Z","registrationStarted":"2026-01-29T16:09:34.441Z","registered":"2026-01-29T16:09:36.566Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003392/rosdok_derivate_0000225960/vanWelzen_Dissertation_2026.pdfAccessible tools for biomolecular data analysis using large-scale knowledge graphsAccessible tools for biomolecular data analysis using large-scale knowledge graphsgnd:1388339641orcid:0000-0002-2486-0246gnd:133515931orcid:0000-0001-6105-2937gnd:1065633742gnd:1239854595orcid:0000-0002-9687-7426gnd:38329-6gnd:10085032-7gnd:1388339641orcid:0000-0002-2486-0246gnd:133515931orcid:0000-0001-6105-2937gnd:1065633742gnd:1239854595orcid:0000-0002-9687-7426gnd:38329-6gnd:10085032-7rosdok_disshab_0000003392-d44559e52gnd:1388339641orcid:0000-0002-2486-0246Matti Welzen vanMatti Welzen vanrosdok_disshab_0000003392-d44559e70gnd:133515931orcid:0000-0001-6105-2937Olaf WolkenhauerOlaf Wolkenhauerrosdok_disshab_0000003392-d44559e87gnd:1065633742Dirk RepsilberDirk Repsilberrosdok_disshab_0000003392-d44559e102gnd:1239854595orcid:0000-0002-9687-7426Anna NiarakisAnna Niarakisrosdok_disshab_0000003392-d44559e118gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003392-d44559e131gnd:10085032-7Universität Rostock. Fakultät für Informatik und ElektrotechnikUniversität Rostock. Fakultät für Informatik und ElektrotechnikMatti Welzen vanOlaf WolkenhauerDirk RepsilberAnna NiarakisUniversität RostockUniversität Rostock. Fakultät für Informatik und ElektrotechnikMatti Welzen vanOlaf WolkenhauerDirk RepsilberAnna NiarakisUniversität RostockUniversität Rostock. Fakultät für Informatik und ElektrotechnikMatti Welzen vanRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005086urn:nbn:de:gbv:28-rosdok_id00005086-210.18453/rosdok_id00005086The interpretation of biomolecular data is often challenging due to the heterogeneity in the structural and functional organization of biological systems. In this thesis, I created knowledge graphs of disease processes, published as interactive Disease Maps, and developed new tools for their analysis. I present (i) the Atlas of Inflammation Resolution (AIR), (ii) the two-dimensional enrichment analysis (2DEA) as a novel network-based enrichment approach, (iii) the Sarcopenia Map linking gastrointestinal diseases and sarcopenia, and (iv) the MASLD Map investigating steatotic liver diseases.20242024Olaf Wolkenhauer (Universität Rostock) ; Dirk Repsilber (Örebro University) ; Anna Niarakis (Université Paul Sabatier)[{"name":"Wolkenhauer, Olaf","affil":"Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Örebro University"},{"name":"Niarakis, Anna","affil":"Université Paul Sabatier"}]Dissertation, Universität Rostock, 2024vorgelegt von Matti van Welzen[xslt]Saxonrosdok/id00005086https://purl.uni-rostock.de/rosdok/id00005086195062908210.18453/rosdok_id00005086urn:nbn:de:gbv:28-rosdok_id00005086-2Matti Welzen vanWelzen Matti vanAccessible tools for biomolecular data analysis using large-scale knowledge graphsDissertationdoctoral thesisUniversität Rostock, Mai 2024The interpretation of biomolecular data is often challenging due to the heterogeneity in the structural and functional organization of biological systems. In this thesis, I created knowledge graphs of disease processes, published as interactive Disease Maps, and developed new tools for their…van Matti WelzenAccessible tools for biomolecular data analysis using large-scale knowledge graphsUniversitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005086MattiWelzenvan1995 -VerfasserInaut13883396410000-0002-2486-0246OlafWolkenhauer1966 -AkademischeR BetreuerIndgs1335159310000-0001-6105-2937Universität RostockDirkRepsilber1971 -AkademischeR BetreuerIndgs1065633742Örebro UniversityAnnaNiarakisAkademischeR BetreuerIndgs12398545950000-0002-9687-7426Université Paul Sabatier38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg10085032-7Universität Rostock. Fakultät für Informatik und Elektrotechnik2004 -Grad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00005086[urn]urn:nbn:de:gbv:28-rosdok_id00005086-2[doi]10.18453/rosdok_id00005086open_access20242024epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:004SDNB:610institution:unirostock.iefstate:published