mycoreobjectrosdok_disshab_0000003589rosdok_disshab_0000003589rosdokdisshabrosdok_derivate_00002282452026-07-21T11:43:33.930Z2026-07-21T10:01:40.807ZMCRJANITOReditorFGpublished1rosdok_derivate_0000228245truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok_id000056671979689067Oau2026-07-212026-07-21T10:26:56ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.14-SNAPSHOT [SCM: "" "" ""] with mode 'DEFAULT'.DissertationHochschulschriftE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomaIn melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.PrabirDhar1987 -VerfasserInaut1412077737StefanieScheuAkademischeR BetreuerIndgs12136791250000-0002-9707-8191Universitätsmedizin Rostock, Institut für ImmunologieHugo IstvanMurua Escobar1973 -AkademischeR BetreuerIndgs12980455XJosefMautnerAkademischeR BetreuerIndgsHelmholtz Zentrum München, Institut für Virologie38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005667urn:nbn:de:gbv:28-rosdok_id00005667-510.18453/rosdok_id00005667570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (IV, 86 Seiten)2025April 2025Universität RostockRostockmonographic20262026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005667Stefanie Scheu (Universitätsmedizin Rostock, Institut für Immunologie) ; Hugo Murua Escobar (Universitätsmedizin Rostock, Institut für Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum München, Institut für Virologie)[{"name":"Scheu, Stefanie","affil":"Universitätsmedizin Rostock, Institut für Immunologie"},{"name":"Murua Escobar, Hugo","affil":"Universitätsmedizin Rostock, Institut für Medizinische Genetik"},{"name":"Mautner, Josef","affil":"Helmholtz Zentrum München, Institut für Virologie"}]Dissertation, Universität Rostock, 2026Interleukin 6vorgelegt von Prabir DharScheu, StefanieUniversitätsmedizin Rostock, Institut für ImmunologieMurua Escobar, HugoUniversitätsmedizin Rostock, Institut für Medizinische GenetikMautner, JosefHelmholtz Zentrum München, Institut für Virologiedoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomaE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomagnd:1412077737gnd:1213679125orcid:0000-0002-9707-8191gnd:12980455Xgnd:38329-6gnd:1029510660gnd:1412077737gnd:1213679125orcid:0000-0002-9707-8191gnd:12980455Xgnd:38329-6gnd:1029510660rosdok_disshab_0000003589-d1139181e52gnd:1412077737Prabir DharPrabir Dharrosdok_disshab_0000003589-d1139181e66gnd:1213679125orcid:0000-0002-9707-8191Stefanie ScheuStefanie Scheurosdok_disshab_0000003589-d1139181e81gnd:12980455XHugo Istvan Murua EscobarHugo Istvan Murua Escobarrosdok_disshab_0000003589-d1139181e95Josef MautnerJosef Mautnerrosdok_disshab_0000003589-d1139181e107gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003589-d1139181e120gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockPrabir DharStefanie ScheuHugo Istvan Murua EscobarJosef MautnerUniversität RostockUniversitätsmedizin RostockPrabir DharStefanie ScheuHugo Istvan Murua EscobarJosef MautnerUniversität RostockUniversitätsmedizin RostockPrabir DharRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005667urn:nbn:de:gbv:28-rosdok_id00005667-510.18453/rosdok_id00005667In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.20252025Stefanie Scheu (Universitätsmedizin Rostock, Institut für Immunologie) ; Hugo Murua Escobar (Universitätsmedizin Rostock, Institut für Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum München, Institut für Virologie)[{"name":"Scheu, Stefanie","affil":"Universitätsmedizin Rostock, Institut für Immunologie"},{"name":"Murua Escobar, Hugo","affil":"Universitätsmedizin Rostock, Institut für Medizinische Genetik"},{"name":"Mautner, Josef","affil":"Helmholtz Zentrum München, Institut für Virologie"}]Dissertation, Universität Rostock, 2026Interleukin 6vorgelegt von Prabir Dharepub.dissertation1 Dhar_Dissertation_2026.pdf 4145293 5c077bc88ddce96c1d9bd2ba10600c44 rosdok_id000056671979689067Oau2026-07-212026-07-21T10:26:56ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.14-SNAPSHOT [SCM: "" "" ""] with mode 'DEFAULT'.DissertationHochschulschriftE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomaIn melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.PrabirDhar1987 -VerfasserInaut1412077737StefanieScheuAkademischeR BetreuerIndgs12136791250000-0002-9707-8191Universitätsmedizin Rostock, Institut für ImmunologieHugo IstvanMurua Escobar1973 -AkademischeR BetreuerIndgs12980455XJosefMautnerAkademischeR BetreuerIndgsHelmholtz Zentrum München, Institut für Virologie38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005667urn:nbn:de:gbv:28-rosdok_id00005667-510.18453/rosdok_id00005667570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (IV, 86 Seiten)2025April 2025Universität RostockRostockmonographic20262026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005667Stefanie Scheu (Universitätsmedizin Rostock, Institut für Immunologie) ; Hugo Murua Escobar (Universitätsmedizin Rostock, Institut für Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum München, Institut für Virologie)[{"name":"Scheu, Stefanie","affil":"Universitätsmedizin Rostock, Institut für Immunologie"},{"name":"Murua Escobar, Hugo","affil":"Universitätsmedizin Rostock, Institut für Medizinische Genetik"},{"name":"Mautner, Josef","affil":"Helmholtz Zentrum München, Institut für Virologie"}]Dissertation, Universität Rostock, 2026Interleukin 6vorgelegt von Prabir Dhar Scheu, Stefanie Universitätsmedizin Rostock, Institut für Immunologie Murua Escobar, Hugo Universitätsmedizin Rostock, Institut für Medizinische Genetik Mautner, Josef Helmholtz Zentrum München, Institut für Virologie 2026-07-21T10:01:40.807Z 2026-07-21T11:43:33.930Z 2026-07-31T11:43:33.947Z editorFG {"identifier":"rosdok/id00005667","type":"local_id","additional":"","service":"MCRLocalID","created":"2026-07-21T10:01:42.286Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00005667-5","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2026-07-21T10:01:42.314Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00005667","type":"purl","additional":"","service":"RosDokPURL","created":"2026-07-21T10:01:42.320Z","registrationStarted":"2026-07-21T11:43:32.634Z"} {"identifier":"10.18453/rosdok_id00005667","type":"doi","additional":"","service":"RosDokDOI","created":"2026-07-21T10:01:42.327Z","registrationStarted":"2026-07-21T11:43:32.230Z","registered":"2026-07-21T11:43:33.925Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003589/rosdok_derivate_0000228245/Dhar_Dissertation_2026.pdfE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomaE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomagnd:1412077737gnd:1213679125orcid:0000-0002-9707-8191gnd:12980455Xgnd:38329-6gnd:1029510660gnd:1412077737gnd:1213679125orcid:0000-0002-9707-8191gnd:12980455Xgnd:38329-6gnd:1029510660rosdok_disshab_0000003589-d1139181e52gnd:1412077737Prabir DharPrabir Dharrosdok_disshab_0000003589-d1139181e66gnd:1213679125orcid:0000-0002-9707-8191Stefanie ScheuStefanie Scheurosdok_disshab_0000003589-d1139181e81gnd:12980455XHugo Istvan Murua EscobarHugo Istvan Murua Escobarrosdok_disshab_0000003589-d1139181e95Josef MautnerJosef Mautnerrosdok_disshab_0000003589-d1139181e107gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003589-d1139181e120gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockPrabir DharStefanie ScheuHugo Istvan Murua EscobarJosef MautnerUniversität RostockUniversitätsmedizin RostockPrabir DharStefanie ScheuHugo Istvan Murua EscobarJosef MautnerUniversität RostockUniversitätsmedizin RostockPrabir DharRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005667urn:nbn:de:gbv:28-rosdok_id00005667-510.18453/rosdok_id00005667In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.20252025Stefanie Scheu (Universitätsmedizin Rostock, Institut für Immunologie) ; Hugo Murua Escobar (Universitätsmedizin Rostock, Institut für Medizinische Genetik) ; Josef Mautner (Helmholtz Zentrum München, Institut für Virologie)[{"name":"Scheu, Stefanie","affil":"Universitätsmedizin Rostock, Institut für Immunologie"},{"name":"Murua Escobar, Hugo","affil":"Universitätsmedizin Rostock, Institut für Medizinische Genetik"},{"name":"Mautner, Josef","affil":"Helmholtz Zentrum München, Institut für Virologie"}]Dissertation, Universität Rostock, 2026Interleukin 6vorgelegt von Prabir Dhar[xslt]Saxonrosdok_id00005667https://purl.uni-rostock.de/rosdok/id00005667197968906710.18453/rosdok_id00005667urn:nbn:de:gbv:28-rosdok_id00005667-5Prabir DharDhar PrabirE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomaDissertationdoctoral thesisUniversität Rostock, April 2025In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the…Prabir DharE2F1-induced IL6 mediates cancer-immune cell crosstalk by modulating T cell response in tumor microenvironment that regulates metastatic properties in melanomaInterleukin 6Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005667PrabirDhar1987 -VerfasserInaut1412077737StefanieScheuAkademischeR BetreuerIndgs12136791250000-0002-9707-8191Universitätsmedizin Rostock, Institut für ImmunologieHugo IstvanMurua Escobar1973 -AkademischeR BetreuerIndgs12980455XJosefMautnerAkademischeR BetreuerIndgsHelmholtz Zentrum München, Institut für Virologie38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00005667[urn]urn:nbn:de:gbv:28-rosdok_id00005667-5[doi]10.18453/rosdok_id00005667open_access20252025epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570SDNB:610institution:unirostock.umrstate:published