10.18453/rosdok_id00005667 Dhar, Prabir Prabir Dhar http://d-nb.info/gnd/1412077737 Universität Rostock 2025 570 Life science 610 Medical sciences Medicine 2025 en https://purl.uni-rostock.de/rosdok/id00005667 urn:nbn:de:gbv:28-rosdok_id00005667-5 In melanoma, E2F1 plays a key role as a regulator of tumor progression. This study identifies a novel gene regulatory network by which E2F1-induced factor IL6 modulates the melanoma microenvironment by altering CD4+ or CD8+ T cell responses. In neighboring CD4+ and CD8+ T cells, IL6 induced the expression of IL10 as well as changes in the secretome profile. In combination with clinical data from TCGA, this study suggests a new melanoma cancer-specific molecular signature, low-E2F1/high-IL10/low-IL6, which is associated with a favourable clinical outcome.