10.18453/rosdok_id00005753 Agrifoglio, Ottavia Ottavia Agrifoglio http://d-nb.info/gnd/1416260889 https://orcid.org/0000-0002-3496-3097 Universität Rostock 2025 610 Medical sciences Medicine 2025 en https://purl.uni-rostock.de/rosdok/id00005753 urn:nbn:de:gbv:28-rosdok_id00005753-8 A murine bile duct ligation (BDL) model was used to study molecular mechanisms of sarcopenia and malnutrition in cholestatic liver disease. C57BL/6J mice randomly underwent a BDL or Sham surgery or were used as controls. Metabolism, inflammatory markers, fractional protein synthesis rate, muscle function and gene expression were assessed. Sarcopenia occurs early, and involves systemic inflammation, a catabolic state, reduced protein synthesis and degradation of muscle proteins. Malnutrition and sarcopenia are present in parallel in, and that they trigger each other in a sort of vicious circle.