mycoreobjectrosdok_disshab_0000003637rosdok_disshab_0000003637rosdokdisshabrosdok_derivate_00002287602026-08-17T15:12:33.284Z2026-08-17T14:46:12.611ZMCRJANITOReditorFGpublished1rosdok_derivate_0000228760truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok_id00005757198197105XOau2026-08-172026-08-17T14:59:57ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.14-SNAPSHOT [SCM: "" "" ""] with mode 'DEFAULT'.DissertationHochschulschriftCorrelations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The findings from the studies presented here illuminate multiple aspects of heterogeneity among patients with ALS and PLS in addition to improving our understanding of the neuroimaging correlates of specific phenotypic characteristics in those patient groups.AnnaliisLehto1996 -VerfasserInaut14166619050000-0003-3459-8226JohannesPrudloAkademischeR BetreuerIndgs1199287717Universitätsmedizin RostockStefanTeipel1970 -AkademischeR BetreuerIndgs1229659220000-0002-3586-3194Universitätsmedizin RostockPeterBedeAkademischeR BetreuerIndgsTrinity College Dublin38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005757urn:nbn:de:gbv:28-rosdok_id00005757-510.18453/rosdok_id00005757150 Psychologie610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (67 Seiten)202521.05.2025Universität RostockRostockmonographic20262026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005757Enthält ZeitschriftenartikelZeitschriftennachweis: Study I - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A, Kurth J, Krause B and Prudlo J (2024) Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis. Journal of Neurology 271: 5290-5300. https://doi.org/10.1007/s00415-024-12388-z ; Study II - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A and Prudlo J (2024) Loss of the ipsilateral silent period in amyotrophic lateral sclerosis is associated with reduced white matter integrity in the motor section of the corpus callosum. Journal of Neurological Sciences 466:123267. https://doi.org/10.1016/j.jns.2024.123267 ; Study III - Lehto A, Schumacher J, Kurth J, Krause B, Kasper E, Teipel S and Prudlo J (2025) Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis. Journal of Neurology 272, 410. https://doi.org/10.1007/s00415-025-13089-xJohannes Prudlo (Universitätsmedizin Rostock) ; Stefan Teipel (Universitätsmedizin Rostock) ; Peter Bede (Trinity College Dublin)[{"name":"Prudlo, Johannes","affil":"Universitätsmedizin Rostock"},{"name":"Teipel, Stefan","affil":"Universitätsmedizin Rostock"},{"name":"Bede, Peter","affil":"Trinity College Dublin"}]Dissertation, Universität Rostock, 2026, Kumulative Dissertationvorgelegt von Annaliis LehtoPrudlo, JohannesUniversitätsmedizin RostockTeipel, StefanUniversitätsmedizin RostockBede, PeterTrinity College Dublindoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:150SDNB:150150 Psychologie150 PsychologySDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengCorrelations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)Correlations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)gnd:1416661905orcid:0000-0003-3459-8226gnd:1199287717gnd:122965922orcid:0000-0002-3586-3194gnd:38329-6gnd:1029510660gnd:1416661905orcid:0000-0003-3459-8226gnd:1199287717gnd:122965922orcid:0000-0002-3586-3194gnd:38329-6gnd:1029510660rosdok_disshab_0000003637-d715424e52gnd:1416661905orcid:0000-0003-3459-8226Annaliis LehtoAnnaliis Lehtorosdok_disshab_0000003637-d715424e68gnd:1199287717Johannes PrudloJohannes Prudlorosdok_disshab_0000003637-d715424e81gnd:122965922orcid:0000-0002-3586-3194Stefan TeipelStefan Teipelrosdok_disshab_0000003637-d715424e98Peter BedePeter Bederosdok_disshab_0000003637-d715424e110gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003637-d715424e123gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockAnnaliis LehtoJohannes PrudloStefan TeipelPeter BedeUniversität RostockUniversitätsmedizin RostockAnnaliis LehtoJohannes PrudloStefan TeipelPeter BedeUniversität RostockUniversitätsmedizin RostockAnnaliis LehtoRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005757urn:nbn:de:gbv:28-rosdok_id00005757-510.18453/rosdok_id00005757The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The findings from the studies presented here illuminate multiple aspects of heterogeneity among patients with ALS and PLS in addition to improving our understanding of the neuroimaging correlates of specific phenotypic characteristics in those patient groups.20252025Enthält ZeitschriftenartikelZeitschriftennachweis: Study I - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A, Kurth J, Krause B and Prudlo J (2024) Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis. Journal of Neurology 271: 5290-5300. https://doi.org/10.1007/s00415-024-12388-z ; Study II - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A and Prudlo J (2024) Loss of the ipsilateral silent period in amyotrophic lateral sclerosis is associated with reduced white matter integrity in the motor section of the corpus callosum. Journal of Neurological Sciences 466:123267. https://doi.org/10.1016/j.jns.2024.123267 ; Study III - Lehto A, Schumacher J, Kurth J, Krause B, Kasper E, Teipel S and Prudlo J (2025) Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis. Journal of Neurology 272, 410. https://doi.org/10.1007/s00415-025-13089-xJohannes Prudlo (Universitätsmedizin Rostock) ; Stefan Teipel (Universitätsmedizin Rostock) ; Peter Bede (Trinity College Dublin)[{"name":"Prudlo, Johannes","affil":"Universitätsmedizin Rostock"},{"name":"Teipel, Stefan","affil":"Universitätsmedizin Rostock"},{"name":"Bede, Peter","affil":"Trinity College Dublin"}]Dissertation, Universität Rostock, 2026, Kumulative Dissertationvorgelegt von Annaliis Lehtoepub.dissertation1 Lehto_Dissertation_2026.pdf 12633945 31b277e43c83d977776585ff06787c8c rosdok_id00005757198197105XOau2026-08-172026-08-17T14:59:57ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.14-SNAPSHOT [SCM: "" "" ""] with mode 'DEFAULT'.DissertationHochschulschriftCorrelations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The findings from the studies presented here illuminate multiple aspects of heterogeneity among patients with ALS and PLS in addition to improving our understanding of the neuroimaging correlates of specific phenotypic characteristics in those patient groups.AnnaliisLehto1996 -VerfasserInaut14166619050000-0003-3459-8226JohannesPrudloAkademischeR BetreuerIndgs1199287717Universitätsmedizin RostockStefanTeipel1970 -AkademischeR BetreuerIndgs1229659220000-0002-3586-3194Universitätsmedizin RostockPeterBedeAkademischeR BetreuerIndgsTrinity College Dublin38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00005757urn:nbn:de:gbv:28-rosdok_id00005757-510.18453/rosdok_id00005757150 Psychologie610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en1 Online-Ressource (67 Seiten)202521.05.2025Universität RostockRostockmonographic20262026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005757Enthält ZeitschriftenartikelZeitschriftennachweis: Study I - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A, Kurth J, Krause B and Prudlo J (2024) Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis. Journal of Neurology 271: 5290-5300. https://doi.org/10.1007/s00415-024-12388-z ; Study II - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A and Prudlo J (2024) Loss of the ipsilateral silent period in amyotrophic lateral sclerosis is associated with reduced white matter integrity in the motor section of the corpus callosum. Journal of Neurological Sciences 466:123267. https://doi.org/10.1016/j.jns.2024.123267 ; Study III - Lehto A, Schumacher J, Kurth J, Krause B, Kasper E, Teipel S and Prudlo J (2025) Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis. Journal of Neurology 272, 410. https://doi.org/10.1007/s00415-025-13089-xJohannes Prudlo (Universitätsmedizin Rostock) ; Stefan Teipel (Universitätsmedizin Rostock) ; Peter Bede (Trinity College Dublin)[{"name":"Prudlo, Johannes","affil":"Universitätsmedizin Rostock"},{"name":"Teipel, Stefan","affil":"Universitätsmedizin Rostock"},{"name":"Bede, Peter","affil":"Trinity College Dublin"}]Dissertation, Universität Rostock, 2026, Kumulative Dissertationvorgelegt von Annaliis Lehto Prudlo, Johannes Universitätsmedizin Rostock Teipel, Stefan Universitätsmedizin Rostock Bede, Peter Trinity College Dublin 2026-08-17T14:46:12.611Z 2026-08-17T15:12:33.284Z 2026-08-27T15:12:33.296Z editorFG {"identifier":"rosdok/id00005757","type":"local_id","additional":"","service":"MCRLocalID","created":"2026-08-17T14:46:12.912Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00005757-5","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2026-08-17T14:46:12.931Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00005757","type":"purl","additional":"","service":"RosDokPURL","created":"2026-08-17T14:46:12.940Z","registrationStarted":"2026-08-17T15:12:32.106Z"} {"identifier":"10.18453/rosdok_id00005757","type":"doi","additional":"","service":"RosDokDOI","created":"2026-08-17T14:46:12.949Z","registrationStarted":"2026-08-17T15:12:31.857Z","registered":"2026-08-17T15:12:33.281Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003637/rosdok_derivate_0000228760/Lehto_Dissertation_2026.pdfCorrelations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)Correlations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)gnd:1416661905orcid:0000-0003-3459-8226gnd:1199287717gnd:122965922orcid:0000-0002-3586-3194gnd:38329-6gnd:1029510660gnd:1416661905orcid:0000-0003-3459-8226gnd:1199287717gnd:122965922orcid:0000-0002-3586-3194gnd:38329-6gnd:1029510660rosdok_disshab_0000003637-d715424e52gnd:1416661905orcid:0000-0003-3459-8226Annaliis LehtoAnnaliis Lehtorosdok_disshab_0000003637-d715424e68gnd:1199287717Johannes PrudloJohannes Prudlorosdok_disshab_0000003637-d715424e81gnd:122965922orcid:0000-0002-3586-3194Stefan TeipelStefan Teipelrosdok_disshab_0000003637-d715424e98Peter BedePeter Bederosdok_disshab_0000003637-d715424e110gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003637-d715424e123gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockAnnaliis LehtoJohannes PrudloStefan TeipelPeter BedeUniversität RostockUniversitätsmedizin RostockAnnaliis LehtoJohannes PrudloStefan TeipelPeter BedeUniversität RostockUniversitätsmedizin RostockAnnaliis LehtoRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00005757urn:nbn:de:gbv:28-rosdok_id00005757-510.18453/rosdok_id00005757The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The findings from the studies presented here illuminate multiple aspects of heterogeneity among patients with ALS and PLS in addition to improving our understanding of the neuroimaging correlates of specific phenotypic characteristics in those patient groups.20252025Enthält ZeitschriftenartikelZeitschriftennachweis: Study I - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A, Kurth J, Krause B and Prudlo J (2024) Cerebral glucose metabolic correlates of cognitive and behavioural impairments in amyotrophic lateral sclerosis. Journal of Neurology 271: 5290-5300. https://doi.org/10.1007/s00415-024-12388-z ; Study II - Lehto A, Schumacher J, Kasper E, Teipel S, Hermann A and Prudlo J (2024) Loss of the ipsilateral silent period in amyotrophic lateral sclerosis is associated with reduced white matter integrity in the motor section of the corpus callosum. Journal of Neurological Sciences 466:123267. https://doi.org/10.1016/j.jns.2024.123267 ; Study III - Lehto A, Schumacher J, Kurth J, Krause B, Kasper E, Teipel S and Prudlo J (2025) Inconsistent primary motor cortex glucose hypometabolism in primary lateral sclerosis. Journal of Neurology 272, 410. https://doi.org/10.1007/s00415-025-13089-xJohannes Prudlo (Universitätsmedizin Rostock) ; Stefan Teipel (Universitätsmedizin Rostock) ; Peter Bede (Trinity College Dublin)[{"name":"Prudlo, Johannes","affil":"Universitätsmedizin Rostock"},{"name":"Teipel, Stefan","affil":"Universitätsmedizin Rostock"},{"name":"Bede, Peter","affil":"Trinity College Dublin"}]Dissertation, Universität Rostock, 2026, Kumulative Dissertationvorgelegt von Annaliis Lehto[xslt]Saxonrosdok_id00005757https://purl.uni-rostock.de/rosdok/id00005757198197105X10.18453/rosdok_id00005757urn:nbn:de:gbv:28-rosdok_id00005757-5Annaliis LehtoLehto AnnaliisCorrelations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)Dissertationdoctoral thesisUniversität Rostock, 21.05.2025The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The…Annaliis LehtoCorrelations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005757AnnaliisLehto1996 -VerfasserInaut14166619050000-0003-3459-8226JohannesPrudloAkademischeR BetreuerIndgs1199287717Universitätsmedizin RostockStefanTeipel1970 -AkademischeR BetreuerIndgs1229659220000-0002-3586-3194Universitätsmedizin RostockPeterBedeAkademischeR BetreuerIndgsTrinity College Dublin38329-6Universität Rostock1419 - 19761990 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin Rostock01.01.2012 -Grad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00005757[urn]urn:nbn:de:gbv:28-rosdok_id00005757-5[doi]10.18453/rosdok_id00005757open_access20252025epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:150SDNB:610institution:unirostock.umrstate:published