Correlations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS)

10.18453/rosdok_id00005757 Lehto, Annaliis Annaliis Lehto http://d-nb.info/gnd/1416661905 https://orcid.org/0000-0003-3459-8226 Correlations of clinical and cognitive characteristics with neuroimaging in patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) Universität Rostock 2025 150 Psychology 610 Medical sciences Medicine 2025 en https://purl.uni-rostock.de/rosdok/id00005757 urn:nbn:de:gbv:28-rosdok_id00005757-5 The aim of this dissertation was to investigate brain structure and glucose metabolism changes in amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) in order to more accurately describe their correlations with patients’ motoric, cognitive or behavioural characteristics. The findings from the studies presented here illuminate multiple aspects of heterogeneity among patients with ALS and PLS in addition to improving our understanding of the neuroimaging correlates of specific phenotypic characteristics in those patient groups.