10.18453/rosdok_id00005802 Saadati, Fariba Fariba Saadati http://d-nb.info/gnd/1419806807 Universität Rostock 2024 570 Life science 590 Zoological sciences 2024 en https://purl.uni-rostock.de/rosdok/id00005802 urn:nbn:de:gbv:28-rosdok_id00005802-5 Breast cancer mortality and treatment side effects highlight the need for alternative or complementary therapies. Physical plasma has emerged as a promising anticancer approach. This thesis explores plasma’s effects on ulcerating breast cancer using 2D/3D in vitro models, in vivo xenografts, patient-derived tissues, and biopsies. Plasma consistently reduced tumor growth, induced programmed cell death, and modulated the tumor microenvironment. It also triggered systemic immune effects and showed no genotoxicity, supporting its safe and effective complementary therapy.