10.18453/rosdok_id00004628 Ballmann, Manfred Manfred Ballmann http://d-nb.info/gnd/115461922 https://orcid.org/0000-0003-4480-1312 Rostock University Medical Center, Department of Pediatrics Wirthgen, Elisa Elisa Wirthgen http://d-nb.info/gnd/1028065590 https://orcid.org/0000-0002-8696-1675 Rostock University Medical Center Quickert, Susann Susann Quickert Rostock University Medical Center Weitzel, Julia Julia Weitzel Rostock University Medical Center Salewski, Birgit Birgit Salewski Rostock University Medical Center University of Rostock, Medical Center 2025 610 Medical sciences Medicine 2025 en https://purl.uni-rostock.de/rosdok/id00004628 urn:nbn:de:gbv:28-rosdok_id00004628-9 Our systematic literature search provides no new, unexpected or unique safety profile for biologics used in asthma therapy in children and adolescents compared to descriptions of the respective product labels. Many common AEs occurred across both short-term and long-term studies. These AEs were expected and in line with prior safety information on these drugs. However, the long-term safety of biologics, particularly that of rare or serious conditions, still requires careful monitoring.