mycoreobjectrosdok_document_0000027285rosdok_document_0000027285rosdokdocumentrosdok_derivate_00002274432026-06-05T14:25:43.592Z2026-06-05T13:12:49.699ZMCRJANITOReditorKLpublished1rosdok_derivate_0000227443truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok_id00005578197254747XOau2026-06-052026-06-05T14:19:55ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.14-SNAPSHOT [SCM: "" "" ""] with mode 'DEFAULT'.ArtikelHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsMany organisms reproduce through non-canonical modes such as parthenogenesis or hybridogenesis (clonal transmission of one parent’s chromosomes), but whether these arise abruptly or stepwise from each other remains unclear. We address this in the stick-insect genus Bacillus , which harbors several hybrid lineages with diverse reproductive modes. From haplotype-resolved phylogenies of >500 wild-caught individuals, we infer a single, recent (~8,000 years) origin of all hybrids. The ancestral hybrid reproduced via hybridogenesis, which subsequently diversified into parthenogenesis and, twice independently, into triploid lineages. Laboratory crosses recapitulate this trajectory, where each step facilitated the next. These findings reveal how a single genomic perturbation can act as a catalyst for evolutionary innovation, turning the loss of sex into a driver of diversification rather than a dead end.AlexanderBrandtVerfasserInaut12389193670000-0003-3742-7692Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, SwitzerlandInstitute for Biosciences, University of Rostock, Rostock 18059, GermanyGuillaumeLavanchyVerfasserInaut0000-0002-3340-7785Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandBiodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, SwedenVincentMérelVerfasserInaut0000-0002-2322-8193Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandLucaSoldiniVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMorganeMassyVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandZoéDumasVerfasserInaut0000-0001-9014-8356Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandEmelyneGaudichauVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMarjorieLabédanVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandFalonPasquier GenoudVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMarcBastardotVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandTanjaSchwanderVerfasserInaut0000-0003-1945-5374Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerlandhttps://purl.uni-rostock.de/rosdok/id00005578urn:nbn:de:gbv:28-rosdok_id00005578-110.18453/rosdok_id00005578570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche FakultätCC BY-NC-ND 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2026University of RostockRostock[accepted author manuscript]monographic20262026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005578[{"name":"Brandt, Alexander","affil":"Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, Switzerland","affil2":"Institute for Biosciences, University of Rostock, Rostock 18059, Germany","orcid":"0000-0003-3742-7692"},{"name":"Lavanchy, Guillaume","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","affil2":"Biodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, Sweden","orcid":"0000-0002-3340-7785"},{"name":"Mérel, Vincent","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0002-2322-8193"},{"name":"Soldini, Luca","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Massy, Morgane","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Dumas, Zoé","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0001-9014-8356"},{"name":"Gaudichau, Emelyne","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Labédan, Marjorie","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Pasquier Genoud, Falon","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Bastardot, Marc","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Schwander, Tanja","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0003-1945-5374"}]Alexander Brandt, Guillaume Lavanchy, Vincent Mérel, Luca Soldini, Morgane Massy, Zoé Dumas, Emelyne Gaudichau, Marjorie Labédan, Falon Pasquier Genoud, Marc Bastardot, Tanja SchwanderProceedings of the National Academy of Sciences (PNAS)20262026Vol. 123, No. 22, e25357001231091-6490Sonderdruck ausdoi.org/10.1073/pnas.2535700123Erscheint auch alsVerlags-AusgabeBrandt, AlexanderDepartment of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, SwitzerlandInstitute for Biosciences, University of Rostock, Rostock 18059, Germany0000-0003-3742-7692Lavanchy, GuillaumeDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandBiodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, Sweden0000-0002-3340-7785Mérel, VincentDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland0000-0002-2322-8193Soldini, LucaDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMassy, MorganeDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandDumas, ZoéDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland0000-0001-9014-8356Gaudichau, EmelyneDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandLabédan, MarjorieDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandPasquier Genoud, FalonDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandBastardot, MarcDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandSchwander, TanjaDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland0000-0003-1945-5374doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.articledoctype:epub.articleArtikelarticlediniPublType:article diniPublType2022:Articleinfo:eu-repo/semantics/articledocumentdiniPublType2022:ArticlediniPublType2022:ArticleWissenschaftlicher ArtikelScientific articleKDSF (Pu11)SDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.cclicenselicenseinfo:work.cclicenseCC-LizenzCC-licenselicenseinfo:work.cclicense.cc-by-nc-ndlicenseinfo:work.cclicense.cc-by-nc-ndCC BY-NC-NDCC BY-NC-NDlicenseinfo:work.cclicense.cc-by-nc-nd.v40licenseinfo:work.cclicense.cc-by-nc-nd.v40CC BY-NC-ND 4.0CC BY-NC-ND 4.0/creativecommons/l/by-nc-nd/4.0/88x31.png[DE-28]Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International$cCC BY-NC-ND 4.0$gCreative Commons$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/https://creativecommons.org/licenses/by-nc-nd/4.0/https://creativecommons.org/licenses/by-nc-nd/4.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsgnd:1238919367orcid:0000-0003-3742-7692orcid:0000-0002-3340-7785orcid:0000-0002-2322-8193orcid:0000-0001-9014-8356orcid:0000-0003-1945-5374gnd:1238919367orcid:0000-0003-3742-7692orcid:0000-0002-3340-7785orcid:0000-0002-2322-8193orcid:0000-0001-9014-8356orcid:0000-0003-1945-5374rosdok_document_0000027285-d8222e48gnd:1238919367orcid:0000-0003-3742-7692Alexander BrandtAlexander Brandtrosdok_document_0000027285-d8222e64orcid:0000-0002-3340-7785Guillaume LavanchyGuillaume Lavanchyrosdok_document_0000027285-d8222e78orcid:0000-0002-2322-8193Vincent MérelVincent Mérelrosdok_document_0000027285-d8222e92Luca SoldiniLuca Soldinirosdok_document_0000027285-d8222e103Morgane MassyMorgane Massyrosdok_document_0000027285-d8222e114orcid:0000-0001-9014-8356Zoé DumasZoé Dumasrosdok_document_0000027285-d8222e128Emelyne GaudichauEmelyne Gaudichaurosdok_document_0000027285-d8222e139Marjorie LabédanMarjorie Labédanrosdok_document_0000027285-d8222e150Falon Pasquier GenoudFalon Pasquier Genoudrosdok_document_0000027285-d8222e161Marc BastardotMarc Bastardotrosdok_document_0000027285-d8222e172orcid:0000-0003-1945-5374Tanja SchwanderTanja SchwanderAlexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderAlexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderAlexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderRostockUniversity of Rostockepub.articlehttps://purl.uni-rostock.de/rosdok/id00005578urn:nbn:de:gbv:28-rosdok_id00005578-110.18453/rosdok_id00005578Many organisms reproduce through non-canonical modes such as parthenogenesis or hybridogenesis (clonal transmission of one parent’s chromosomes), but whether these arise abruptly or stepwise from each other remains unclear. We address this in the stick-insect genus Bacillus , which harbors several hybrid lineages with diverse reproductive modes. From haplotype-resolved phylogenies of >500 wild-caught individuals, we infer a single, recent (~8,000 years) origin of all hybrids. The ancestral hybrid reproduced via hybridogenesis, which subsequently diversified into parthenogenesis and, twice independently, into triploid lineages. Laboratory crosses recapitulate this trajectory, where each step facilitated the next. These findings reveal how a single genomic perturbation can act as a catalyst for evolutionary innovation, turning the loss of sex into a driver of diversification rather than a dead end.20262026[accepted author manuscript]Proceedings of the National Academy of Sciences (PNAS)20262026Proceedings of the National Academy of Sciences (PNAS)20262026Vol. 123, No. 22, e25357001231091-6490Sonderdruck aus1091-6490doi.org/10.1073/pnas.2535700123Erscheint auch alsVerlags-Ausgabedoi.org/10.1073/pnas.2535700123[{"name":"Brandt, Alexander","affil":"Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, Switzerland","affil2":"Institute for Biosciences, University of Rostock, Rostock 18059, Germany","orcid":"0000-0003-3742-7692"},{"name":"Lavanchy, Guillaume","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","affil2":"Biodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, Sweden","orcid":"0000-0002-3340-7785"},{"name":"Mérel, Vincent","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0002-2322-8193"},{"name":"Soldini, Luca","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Massy, Morgane","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Dumas, Zoé","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0001-9014-8356"},{"name":"Gaudichau, Emelyne","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Labédan, Marjorie","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Pasquier Genoud, Falon","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Bastardot, Marc","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Schwander, Tanja","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0003-1945-5374"}]Alexander Brandt, Guillaume Lavanchy, Vincent Mérel, Luca Soldini, Morgane Massy, Zoé Dumas, Emelyne Gaudichau, Marjorie Labédan, Falon Pasquier Genoud, Marc Bastardot, Tanja Schwanderepub.article1 Brandt_Hybridogenesis_2026.pdf 5307809 ee664cb09a513794748f45eb35df83ca rosdok_id00005578197254747XOau2026-06-052026-06-05T14:19:55ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.14-SNAPSHOT [SCM: "" "" ""] with mode 'DEFAULT'.ArtikelHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsMany organisms reproduce through non-canonical modes such as parthenogenesis or hybridogenesis (clonal transmission of one parent’s chromosomes), but whether these arise abruptly or stepwise from each other remains unclear. We address this in the stick-insect genus Bacillus , which harbors several hybrid lineages with diverse reproductive modes. From haplotype-resolved phylogenies of >500 wild-caught individuals, we infer a single, recent (~8,000 years) origin of all hybrids. The ancestral hybrid reproduced via hybridogenesis, which subsequently diversified into parthenogenesis and, twice independently, into triploid lineages. Laboratory crosses recapitulate this trajectory, where each step facilitated the next. These findings reveal how a single genomic perturbation can act as a catalyst for evolutionary innovation, turning the loss of sex into a driver of diversification rather than a dead end.AlexanderBrandtVerfasserInaut12389193670000-0003-3742-7692Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, SwitzerlandInstitute for Biosciences, University of Rostock, Rostock 18059, GermanyGuillaumeLavanchyVerfasserInaut0000-0002-3340-7785Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandBiodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, SwedenVincentMérelVerfasserInaut0000-0002-2322-8193Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandLucaSoldiniVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMorganeMassyVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandZoéDumasVerfasserInaut0000-0001-9014-8356Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandEmelyneGaudichauVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMarjorieLabédanVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandFalonPasquier GenoudVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMarcBastardotVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandTanjaSchwanderVerfasserInaut0000-0003-1945-5374Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerlandhttps://purl.uni-rostock.de/rosdok/id00005578urn:nbn:de:gbv:28-rosdok_id00005578-110.18453/rosdok_id00005578570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche FakultätCC BY-NC-ND 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2026University of RostockRostock[accepted author manuscript]monographic20262026Universitätsbibliothek RostockRostock2026Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005578[{"name":"Brandt, Alexander","affil":"Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, Switzerland","affil2":"Institute for Biosciences, University of Rostock, Rostock 18059, Germany","orcid":"0000-0003-3742-7692"},{"name":"Lavanchy, Guillaume","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","affil2":"Biodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, Sweden","orcid":"0000-0002-3340-7785"},{"name":"Mérel, Vincent","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0002-2322-8193"},{"name":"Soldini, Luca","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Massy, Morgane","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Dumas, Zoé","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0001-9014-8356"},{"name":"Gaudichau, Emelyne","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Labédan, Marjorie","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Pasquier Genoud, Falon","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Bastardot, Marc","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Schwander, Tanja","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0003-1945-5374"}]Alexander Brandt, Guillaume Lavanchy, Vincent Mérel, Luca Soldini, Morgane Massy, Zoé Dumas, Emelyne Gaudichau, Marjorie Labédan, Falon Pasquier Genoud, Marc Bastardot, Tanja SchwanderProceedings of the National Academy of Sciences (PNAS)20262026Vol. 123, No. 22, e25357001231091-6490Sonderdruck ausdoi.org/10.1073/pnas.2535700123Erscheint auch alsVerlags-Ausgabe Brandt, Alexander Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, Switzerland Institute for Biosciences, University of Rostock, Rostock 18059, Germany 0000-0003-3742-7692 Lavanchy, Guillaume Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Biodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, Sweden 0000-0002-3340-7785 Mérel, Vincent Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland 0000-0002-2322-8193 Soldini, Luca Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Massy, Morgane Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Dumas, Zoé Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland 0000-0001-9014-8356 Gaudichau, Emelyne Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Labédan, Marjorie Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Pasquier Genoud, Falon Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Bastardot, Marc Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland Schwander, Tanja Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland 0000-0003-1945-5374 2026-06-05T13:12:49.699Z 2026-06-05T14:25:43.592Z 2026-06-15T14:25:43.604Z editorKL {"identifier":"rosdok/id00005578","type":"local_id","additional":"","service":"MCRLocalID","created":"2026-06-05T13:12:49.709Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00005578-1","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2026-06-05T13:12:49.715Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00005578","type":"purl","additional":"","service":"RosDokPURL","created":"2026-06-05T13:12:49.719Z","registrationStarted":"2026-06-05T14:25:42.279Z"} {"identifier":"10.18453/rosdok_id00005578","type":"doi","additional":"","service":"RosDokDOI","created":"2026-06-05T13:12:49.722Z","registrationStarted":"2026-06-05T14:25:42.037Z","registered":"2026-06-05T14:25:43.589Z"} MCRJANITORfulltextfile/rosdok_document_0000027285/rosdok_derivate_0000227443/Brandt_Hybridogenesis_2026.pdfHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsgnd:1238919367orcid:0000-0003-3742-7692orcid:0000-0002-3340-7785orcid:0000-0002-2322-8193orcid:0000-0001-9014-8356orcid:0000-0003-1945-5374gnd:1238919367orcid:0000-0003-3742-7692orcid:0000-0002-3340-7785orcid:0000-0002-2322-8193orcid:0000-0001-9014-8356orcid:0000-0003-1945-5374rosdok_document_0000027285-d8222e48gnd:1238919367orcid:0000-0003-3742-7692Alexander BrandtAlexander Brandtrosdok_document_0000027285-d8222e64orcid:0000-0002-3340-7785Guillaume LavanchyGuillaume Lavanchyrosdok_document_0000027285-d8222e78orcid:0000-0002-2322-8193Vincent MérelVincent Mérelrosdok_document_0000027285-d8222e92Luca SoldiniLuca Soldinirosdok_document_0000027285-d8222e103Morgane MassyMorgane Massyrosdok_document_0000027285-d8222e114orcid:0000-0001-9014-8356Zoé DumasZoé Dumasrosdok_document_0000027285-d8222e128Emelyne GaudichauEmelyne Gaudichaurosdok_document_0000027285-d8222e139Marjorie LabédanMarjorie Labédanrosdok_document_0000027285-d8222e150Falon Pasquier GenoudFalon Pasquier Genoudrosdok_document_0000027285-d8222e161Marc BastardotMarc Bastardotrosdok_document_0000027285-d8222e172orcid:0000-0003-1945-5374Tanja SchwanderTanja SchwanderAlexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderAlexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderAlexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderRostockUniversity of Rostockepub.articlehttps://purl.uni-rostock.de/rosdok/id00005578urn:nbn:de:gbv:28-rosdok_id00005578-110.18453/rosdok_id00005578Many organisms reproduce through non-canonical modes such as parthenogenesis or hybridogenesis (clonal transmission of one parent’s chromosomes), but whether these arise abruptly or stepwise from each other remains unclear. We address this in the stick-insect genus Bacillus , which harbors several hybrid lineages with diverse reproductive modes. From haplotype-resolved phylogenies of >500 wild-caught individuals, we infer a single, recent (~8,000 years) origin of all hybrids. The ancestral hybrid reproduced via hybridogenesis, which subsequently diversified into parthenogenesis and, twice independently, into triploid lineages. Laboratory crosses recapitulate this trajectory, where each step facilitated the next. These findings reveal how a single genomic perturbation can act as a catalyst for evolutionary innovation, turning the loss of sex into a driver of diversification rather than a dead end.20262026[accepted author manuscript]Proceedings of the National Academy of Sciences (PNAS)20262026Proceedings of the National Academy of Sciences (PNAS)20262026Vol. 123, No. 22, e25357001231091-6490Sonderdruck aus1091-6490doi.org/10.1073/pnas.2535700123Erscheint auch alsVerlags-Ausgabedoi.org/10.1073/pnas.2535700123[{"name":"Brandt, Alexander","affil":"Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, Switzerland","affil2":"Institute for Biosciences, University of Rostock, Rostock 18059, Germany","orcid":"0000-0003-3742-7692"},{"name":"Lavanchy, Guillaume","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","affil2":"Biodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, Sweden","orcid":"0000-0002-3340-7785"},{"name":"Mérel, Vincent","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0002-2322-8193"},{"name":"Soldini, Luca","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Massy, Morgane","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Dumas, Zoé","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0001-9014-8356"},{"name":"Gaudichau, Emelyne","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Labédan, Marjorie","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Pasquier Genoud, Falon","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Bastardot, Marc","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland"},{"name":"Schwander, Tanja","affil":"Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland","orcid":"0000-0003-1945-5374"}]Alexander Brandt, Guillaume Lavanchy, Vincent Mérel, Luca Soldini, Morgane Massy, Zoé Dumas, Emelyne Gaudichau, Marjorie Labédan, Falon Pasquier Genoud, Marc Bastardot, Tanja Schwander[xslt]Saxonrosdok_id00005578https://purl.uni-rostock.de/rosdok/id00005578197254747X10.18453/rosdok_id00005578urn:nbn:de:gbv:28-rosdok_id00005578-1Alexander Brandt, Guillaume Lavanchy, Vincent Mérel, Luca Soldini, Morgane Massy, Zoé Dumas, Emelyne Gaudichau, Marjorie Labédan, Falon Pasquier Genoud, Marc Bastardot, Tanja SchwanderBrandt Alexander, Lavanchy Guillaume, Mérel Vincent, Soldini Luca, Massy Morgane, Dumas Zoé, Gaudichau Emelyne, Labédan Marjorie, Pasquier Genoud Falon, Bastardot Marc, Schwander TanjaHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsArtikelarticle[accepted author manuscript], University of Rostock, 2026Many organisms reproduce through non-canonical modes such as parthenogenesis or hybridogenesis (clonal transmission of one parent’s chromosomes), but whether these arise abruptly or stepwise from each other remains unclear. We address this in the stick-insect genus Bacillus , which harbors several…Alexander BrandtGuillaume LavanchyVincent MérelLuca SoldiniMorgane MassyZoé DumasEmelyne GaudichauMarjorie LabédanFalon Pasquier GenoudMarc BastardotTanja SchwanderHybridogenesis as an intermediate step between sexual reproduction and parthenogenesis in stick insectsProceedings of the National Academy of Sciences (PNAS)Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00005578AlexanderBrandtVerfasserInaut12389193670000-0003-3742-7692Department of Ecology and Evolution, University of Lausanne, Lausanne CH-1015, SwitzerlandInstitute for Biosciences, University of Rostock, Rostock 18059, GermanyGuillaumeLavanchyVerfasserInaut0000-0002-3340-7785Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandBiodiversity and Evolution Unit, Department of Biology, Lund University. Ekologihuset, Sölvegatan 37, 223 62 Lund, SwedenVincentMérelVerfasserInaut0000-0002-2322-8193Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandLucaSoldiniVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMorganeMassyVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandZoéDumasVerfasserInaut0000-0001-9014-8356Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandEmelyneGaudichauVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMarjorieLabédanVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandFalonPasquier GenoudVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandMarcBastardotVerfasserInautDepartment of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, SwitzerlandTanjaSchwanderVerfasserInaut0000-0003-1945-5374Department of Ecology and Evolution, University of Lausanne, UNIL Sorge, Le Biophore, CH - 1015 Lausanne, Switzerland[purl]https://purl.uni-rostock.de/rosdok/id00005578[urn]urn:nbn:de:gbv:28-rosdok_id00005578-1[doi]10.18453/rosdok_id00005578open_access20262026epoch:21th_centuryrfc5646:endoctype:epub.articleaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published