goto contents

Stephan Beckmann

Überleben, Differenzierung und funktionelle Auswirkungen transplantierter CSM14.1 Progenitorzellen in neonatalen 6-OHDA-läsionierten Ratten

Universität Rostock, 2007

Abstract: The present study analyzed whether grafts of the mesencephalic progenitor cell line CSM14.1 into the neonatal rat CPu differentiate into neurons and whether this is accompanied by a functional improvement in 6-OHDA-lesioned animals. Rats bilaterally lesioned at postnatal day 1 by intraventricular 6-OHDA-injections 2 days later received 100000 CSM14.1 cells into the right CPu. Five weeks after grafting, the cylinder test was performed. Brain slices immunostained for tyrosine hydroxylase (TH) were quantified by optical densitometry. CSM14.1 cells differentiate into TH-containing neurons, which contribute to the preferred forelimb use, indicating a functional integration of CSM14.1 cells.

doctoral thesis   free access    


OPACGVKDataCite Commons


all rights reserved

This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz).