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Karolin Krüger

Synthesis of Biologically Active N-Heterocycles and Amines via Catalytic Hydroamination of Alkynes

Universität Rostock, 2008

https://doi.org/10.18453/rosdok_id00000362

Abstract: This thesis presents new syntheses of N-heterocycles and amines. Building up on our prior studies in titanium-catalyzed hydroamination of alkynes we discovered zinc salts as new hydroamination catalysts. Zinc chloride and zinc triflate were successfully applied in the intermolecular hydroamination of terminal alkynes for the synthesis of various substituted indole derivatives, pyrazolines and pyrazoles, pyridazinones as well as amines. Additional functionalization reactions on special synthesized indole structures lead to pharmaceutically and biologically interesting substances.

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