| title: |
| Synthesis and Catalytic Functionalization of Biologically Active Indoles |
|
| contributing persons: |
| Nicolle Schwarz[VerfasserIn] |
 |
137450508 |
| Matthias Beller
, Prof. Dr.[AkademischeR BetreuerIn] |
| Armin Börner
, Prof. Dr.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Of fundamental importance in nature are substituted indoles. The thesis presents the
synthesis of new indole derivatives and their functionalization to potential 5-HT6
receptor ligands. Based on our prior synthesis to indole analogues we investigated
a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination
of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles
and their further application in several catalytic reactions. Buchwald-Hartwig amination,
C-O cross-
coupling and sulfonylation were utilized and optimized.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 540 Chemistry & allied sciences |
|
| |
publication /
production: |
|
Rostock: Universität Rostock
|
|
2008
|
|
| |
| identifiers: |
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| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000179 |
| created / modified: |
27.02.2009 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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