Synthesis and Catalytic Functionalization of Biologically Active Indoles

Nicolle Schwarz

doi:10.18453/rosdok_id00000427

Nicolle Schwarz

Synthesis and Catalytic Functionalization of Biologically Active Indoles

Universität Rostock, 2008

https://doi.org/10.18453/rosdok_id00000427

Abstract: Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized.

Dissertation Freier Zugang

Titel:

Synthesis and Catalytic Functionalization of Biologically Active Indoles

Beteiligte Personen:

Nicolle Schwarz[VerfasserIn]
	137450508
Matthias Beller , Prof. Dr.[AkademischeR BetreuerIn]
Armin Börner , Prof. Dr.[AkademischeR BetreuerIn]

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

Of fundamental importance in nature are substituted indoles. The thesis presents the synthesis of new indole derivatives and their functionalization to potential 5-HT6 receptor ligands. Based on our prior synthesis to indole analogues we investigated a synthetic strategy to innovative indole scaffolds via Ti- or Zn-catalyzed hydrohydrazination of terminal alkynes. We developed the pharmaceutical interesting class of 3-silyloxyindoles and their further application in several catalytic reactions. Buchwald-Hartwig amination, C-O cross- coupling and sulfonylation were utilized and optimized. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

540 Chemie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2008