Universität Rostock, 2009
Abstract: This work analyzed the regulation of O2 dependent gene expression in the obligate anaerobe eubacterium Clostridium acetobutylicum. The protein PerR was identified as the central repressor of the O2 stress reponse of C. acetobutylicum. PerR regulates alternative enzymes of its central energy metabolism as well as a reductive detoxification system. These results gave evidence that even obligate anaerobes employ a variety of mechanisms to adapt to environmental O2.
doctoral thesis free access