| title: |
| Charakterisierung neuraler Stammzellen (CSM14.1-Zellen) in vitro und in vivo nach
Transplantation in das Striatum von Hemiparkinson-Ratten |
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| contributing persons: |
| Stefan Haas[VerfasserIn] |
 |
136643043 |
| Andreas Wree
, Prof. Dr. med.[AkademischeR BetreuerIn] |
| Dieter G. Weiss
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
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| abstract: |
|
Ich charakterisierte CSM14.1-Zellen in vitro und in vivo nach Transplantation in das
Striatum von Hemiparkinson-Ratten. In vitro wurden Markerproteine für Progenitorzellen,
dopaminerge (DAerge) Progenitoren und Nervenzellen während der Differenzierung untersucht.
Hierbei wurde ein Ablauf der DAergen Differenzierung beobachtet wie auch während der
Embryonalentwicklung im Nagergehirn abläuft. Nach Transplantation migrierten PKH26-markierte
CSM14.1-Zellen 400 µm und exprimierten GFAP. Eine DAerge Differenzierung unterblieb.
Apomorphin-induzierte Rotationen unterschieden sich nicht von Kontrollen.
[German] |
|
I characterised CSM14.1-cells in vitro and in vivo after transplantation into the
striatum of Hemiparkinsonian rats. In vitro the expression of markers for neural stem
cells, dopaminergic (DAergic) progenitors and neurons during differentiation was investigated.
CSM14.1-cells underwent a similar DAergic differentiation as in rodent brains. After
transplantation PKH26-labelled CSM14.1-cells were viable and mainly expressed GFAP.
DAergic differentiation was not observed and a DAergic reinnervation of the striatum
did not occur. Apomorphine-induced rotations did not differ from those of controls.
[English] |
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| document type: |
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| institution: |
| Faculty of Mathematics and Natural Sciences |
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| language: |
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| subject class (DDC): |
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publication /
production: |
Rostock
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Rostock: Universität Rostock
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2008
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| identifiers: |
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| access condition: |
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| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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| RosDok id: |
rosdok_disshab_0000000244 |
| created / modified: |
03.07.2009 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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