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Anne Brennführer Dr.

Palladium/di-1-adamantyl-n-butylphosphine-catalyzed Carbonylation Reactions

Universität Rostock, 2008

Abstract: Within this thesis several homogeneous palladium-catalyzed carbonylation reactions in the presence of carbon monoxide were investigated. In the course of our studies, the superior performance of the catalyst system palladium acetate/di-1-adamantyl-n-butylphosphine (cataCXium® A) in comparison to established palladium catalysts was demonstrated for both reductive carbonylations and alkoxycarbonylations of aryl and vinyl bromides. Hence, a variety of (hetero)aromatic aldehydes and carboxylic acid derivatives (esters, amides, acids) were successfully synthesized, among them novel biologically interesting indolylmaleimides. Furthermore, an efficient method for the synthesis of non-steroidal anti-inflammatory drugs such as ketoprofen and suprofen was developed.

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