| title: |
| In vitro and in vivo characterization of neural progenitor cells as putative candidates
for experimental studies and clinical trials in cell replacement therapy for neurodegenerative
diseases |
|
| contributing persons: |
| Marine Hovakimyan[VerfasserIn] |
 |
138627258 |
| Oliver Schmitt
, Prof. Dr. med.[AkademischeR BetreuerIn] |
| Dieter G. Weiss
, Prof. Dr. rer.[AkademischeR BetreuerIn] |
| Ingo Nolte
, Prof. Dr. med. vet.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Fetal conditionally immortalized striatal cells ST14A and human mesencephalic neural
progenitor cells (NPCs) were studied with respect to proliferation and differentiation
in in vitro experiments. In in vivo experiments, human NPCs were investigated after
transplantation into neonatal and adult hemiparkinsonian rat striatum. The survival,
migration and dopaminergic (DAergic) differentiation of human NPCs in the host brain
was investigated. Improvement in lesion-induced motor impairment has been demonstrated
in both groups of hemiparkinsonian rats, independently from DA-ergic differentiation.
[English] |
|
In der vorliegenden Arbeit wurden fetale immortalisierte Zellen der Linie ST14 A und
humane mesenzephale Progenitorzellen (NPC) in vitro untersucht. In in vivo-Experimenten
wurden die humanen NPC nach Transplantation in das Striatum neonataler oder adulter
Heminparkinson-Ratten untersucht. In diesen Transplantationsstudien lag der Hauptaspekt
auf dem Überleben, der Migration und der dopaminergen Differenzierung der humanen
NPC im Wirtsgewebe. Eine Verbesserung des motorischen Verhaltens konnte in beiden
Transplantationsmodellen gezeigt werden, unabhängig von dopaminerger Differenzierung.
[German] |
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| document type: |
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| institution: |
| Faculty of Mathematics and Natural Sciences |
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| language: |
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| subject class (DDC): |
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| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2008
|
|
| |
| identifiers: |
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| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000263 |
| created / modified: |
15.07.2009 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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