Universität Rostock, 2008
Abstract: We investigated the pharmacokinetics and ability of tissue penetration of the two carbapenems ertapenem and meropenem in acute necrotizing pankreatitis in a rat-modell. Unlike eropenem no ertapenem could be found in pancreatic tissue. Reasons are due to the physico-chemical properties of ertapenem. Serum concentrations of both carbapenems exceeded MIC. Findings of this study are transferable into humans as well. Further investigation of ertapenem concentrations in intertitial fluid are necessary.
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