Universität Rostock, 2009
Abstract: The effect of the statin atorvastatin on the expression of genes were investigated which could be important in the pathogenesis of the EAE und probably also in the MS. In addition, effects of atorvastatin were tested on the expression of candidates of proteins in neural progenitor cells in vitro, to point out possible influence of regenerative processes in nerve tissue by statins. The investigated proteins are potential indications for responder and non-responder in different animal stems and probably also in MS-patients.
doctoral thesis free access