Universität Rostock, 2009
Abstract: PTHR1 and LEF1 were analyzed as functional candidate genes for the inverted teat defect in pigs. SNP in both genes could be shown as significantly associated with inverted teats. QTL analyses revealed significant QTL on twelve chromosomes in an experimental and five chromosomes in a commercial pig population. That enabled the information about novel positional candidate genes. Adjacent microarray analyses of epithelial and mesenchymal teat tissues of affected and non-affected animals offered differentially regulated genes. Constitutive quantitative real-time analyses of FGFR2, GHR, HGF, PDGFA, PDGFRA, PDGFB and VEGF revealed significant differential expressions in the compared tissues.
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