title: |
Molecular mechanisms controlling the tissue-specific activity of the nutritionally
regulated promoter I of the acetyl-CoA carboxylase-alpha encoding gene in cattle |
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contributing persons: |
Xuanming Shi[VerfasserIn] |
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13974049X |
Hans-Martin Seyfert
, Prof. Dr.[AkademischeR BetreuerIn] |
Martin Hagemann
, Prof. Dr.[AkademischeR BetreuerIn] |
Monika Schweigel
, PD. Dr.[AkademischeR BetreuerIn] |
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contributing corporate bodies: |
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
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2147083-2 |
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abstract: |
We analyzed molecular mechanisms controlling the activity of the nutritionally regulated
promoter I (PI) of the bovine acetyl-CoA-carboxylase-alpha gene. PI-activity is driven
by NF-Y and C/EBP factors having bound to high affinity sites on the proximal PI.
However, both factors may also bind to low affinity sites on the distal PI. From there,
they act as repressors of PI. We found that NF-Y may diminish and block C/EBP-beta
mediated PI activation, even in trans, through direct factor interaction. Alterations
in the concentrations of both factors apparently regulate the tissue specific PI-activity.
[English] |
Es wurden die molekularen Mechanismen untersucht, welche die Aktivität des ernährungsabhängig
regulierten Promotors I (PI) des bovinen Acetyl-CoA-carboxylase-alpha Gens bestimmen.
NF-Y und C/EBP Faktoren treiben die PI-Aktivität, wenn sie an proximale Bindungsstellen
hoher Affinität gebunden haben. Sie drosseln jedoch PI-Aktivität nach Bindung an distale
Ansatzstellen geringer Bindungsaffinität. NF-Y blockiert die Aktivierungsfähigkeit
von C/EBP-beta, auch im Tran, durch direkte Faktoren-Interaktion. Veränderungen der
Konzentrationen beider Faktoren bestimmen die gewebespezifische PI-Aktivität.
[German] |
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document type: |
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institution: |
Faculty of Mathematics and Natural Sciences |
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language: |
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subject class (DDC): |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2009
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000000328 |
created / modified: |
20.04.2011 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |