| title: |
| The role of NF-kappaB and C/EBP factors during pathogen-mediated activation of bovine
interleukin 8 and beta-defensin in mammary epithelial cells |
|
| contributing persons: |
| Shuzhen Liu[VerfasserIn] |
 |
139743367 |
| Hans-Martin Seyfert
, Prof. Dr.[AkademischeR BetreuerIn] |
| Dieter G. Weiss
, Prof. Dr.[AkademischeR BetreuerIn] |
| Ulrike Gimsa
, PD Dr.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Molecular mechanisms of pathogen-induced activation of the IL-8 and LAP genes were
investigated in Mammary Epithelial Cells. Activity of the resting IL-8 promoter is
inhibited by NF-kappaB p65, but activated quickly after pathogen contact by C/EBP
factors. Conversely, NF-kappaB p65 drives LAP expression some time after pathogen
induction, while C/EBP factors attenuate activity of this promoter. Hence, in the
very same cell type NF-kappaB p65 and C/EBP factors antagonistically regulate both
immune relevant genes before and after pathogen mediated stimulation.
[English] |
|
Molekulare Mechanismen der Pathogen-induzierten Expression des Cytokingenes IL-8 und
des beta-Defensin Gens LAP wurden in Milchdrüsen Epithelzellen (MEC) untersucht. Die
Expression des ruhenden IL-8-Promotors wird durch NF-kappaB p65 blockiert, aber schnell
nach Pathogen Kontakt durch C/EBP-Faktoren induziert. Umgekehrt treibt NF-kappaB p65
die LAP-Expression einige Zeit nach Pathogen-Kontakt, während C/EBP-Faktoren die Aktivität
dieses Promotors mindern. In dem gleichen Zelletyp werden also diese beiden immun-relevanten
Gene gegensätzlich reguliert durch die Faktoren NF-kappaB p65 und C/EBP.
[German] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
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| subject class (DDC): |
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| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2009
|
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| |
| identifiers: |
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| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000329 |
| created / modified: |
20.04.2011 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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