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Christoph Müller

Der Einfluss von cis-Hydroxy-L-Prolin (CHP) auf die Pankreaskarzinom-Zelllinie DSL6A der Ratte

Universität Rostock, 2008

Abstract: Cis-hydroxyproline(CHP) induced ER-stress leads to inhibition of proliferation of pancreas carcinoma cells. In addition, initiation of ER-stress machinery by CHP activates intracellular proteolytic processes, including caspase-independent FAK degradation and loss of cell adherence. Prolonged ER-Stress caused by CHP finally resulted in apoptotic cell death.

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