| title: |
| Matrix Metalloproteinasen und deren Inhibitoren im Verlauf der experimentellen chronischen
Pankreatitis |
|
| contributing persons: |
| Ib Jammer[VerfasserIn] |
 |
141253037 |
| Jörg Emmrich
, Prof. Dr.[AkademischeR BetreuerIn] |
| Ernst Klar
, Prof. Dr.[AkademischeR BetreuerIn] |
| Peter Malfertheiner
, Prof. Dr.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
|
1029510660 |
|
| |
| abstract: |
|
Ziel der vorliegenden Arbeit waren Untersuchungen zur Expression von Matrix Metalloproteinasen
(MMPs) und deren Inhibitoren, den Tissue Inhibitors of Matrix Metalloproteinases (TIMPs),
im Verlauf einer tierexperimentellen chronischen Pankreatitis sowie in kultivierten
pankreatische Stellatezellen. Ein Anstieg der Expression von TIMPs und MMPs während
der experimentellen Pankreatitis weist auf einen Zusammenhang zwischen den Proteinasen
und ihren Inhibitoren hin. Dieser begünstigt möglicherweise die Infiltration immunokompetenter
Zellen, welche zu einer Verstärkung und zur Chronifizierung der Pankreatitis beiträgt.
[German] |
|
In order to investigate the matrix turnover during the course of the experimental
pancreatitis, we studied the expression of the extracellular matrix (ECM) degrading
enzymes, the matrix metalloproteinases (MMP) and their inhibitors, the tissue inhibitors
of metalloproteinases (TIMP), in the pancreas, as well as the MMP activity in Stellate
cells culture. Increased expressions of TIMPs during the experimental pancreatitis
accompanied by differences in MMP-RNA levels and elevated MMP activity in activated
stellate cells indicate an important role for the relation between proteinases and
their inhibitors.
[German] |
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| document type: |
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| institution: |
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| language: |
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| subject class (DDC): |
| 610 Medical sciences Medicine |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2008
|
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| identifiers: |
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| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000435 |
| created / modified: |
08.06.2010 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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