title: |
Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus
im murinen Modell des akuten septischen Leberversagens |
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contributing persons: |
Anke Hildebrandt[VerfasserIn] |
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141580720 |
Brigitte Vollmar
, Prof. Dr. med.[AkademischeR BetreuerIn] |
Jochen Schubert
, Prof. Dr. med. Dipl. Chem.[AkademischeR BetreuerIn] |
Johannes Hoffmann
, Apl. Prof. Dr. med.[AkademischeR BetreuerIn] |
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contributing corporate bodies: |
Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
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1029510660 |
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abstract: |
We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on
the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice
were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6
hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage,
a drop of total adenosine nucleotide level and an increased malondialdehyde production.
In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a
net result, ATP8 mutant mice showed lower transaminase release and better survival
rate.
[English] |
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document type: |
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institution: |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2009
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000000458 |
created / modified: |
15.06.2010 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |