Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens

Anke Hildebrandt

doi:10.18453/rosdok_id00000675

Anke Hildebrandt

Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens

Universität Rostock, 2009

https://doi.org/10.18453/rosdok_id00000675

Abstract: We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6 hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage, a drop of total adenosine nucleotide level and an increased malondialdehyde production. In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a net result, ATP8 mutant mice showed lower transaminase release and better survival rate.

Dissertation Freier Zugang

Titel:

Die Mutation des mitochondrialen ATP8 Gens verbessert den hepatischen Energiestatus im murinen Modell des akuten septischen Leberversagens

Beteiligte Personen:

Anke Hildebrandt[VerfasserIn]
	141580720
Brigitte Vollmar , Prof. Dr. med.[AkademischeR BetreuerIn]
Jochen Schubert , Prof. Dr. med. Dipl. Chem.[AkademischeR BetreuerIn]
Johannes Hoffmann , Apl. Prof. Dr. med.[AkademischeR BetreuerIn]

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

We investigated whether a mutation in the ATPase subunit-8 gene exerts effects on the course of endotoxemic acute liver failure in mice. Wildtype and ATP8 mutant mice were challenged with D-galactosamine and E. coli lipopolysaccharide and studied 6 hrs thereafter. Induction of endotoxemic liver failure provoked marked liver damage, a drop of total adenosine nucleotide level and an increased malondialdehyde production. In contrast, ATP levels in livers ATP8 mutants remained significantly higher. As a net result, ATP8 mutant mice showed lower transaminase release and better survival rate. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Deutsch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2009