Universität Rostock, 2008
Abstract: The purpose of the investigations was the development of drug-eluting stents (DES) for applications in cardiology, vessel surgery and urology, and the characterization of DES regarding their functionality in vitro and in vivo. In order to avoid late foreign body reactions degradable polymeric stent bodies and stent coatings were developed. The drug release behaviour was controlled by the choice of polymer, the layer thickness, the layer composition and the drug content in the coating. Alternatively, the wet chemical linkage of drugs on the surface of the polymeric coatings was studied.
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