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Syed Furquan Ahmad

Influence of Fcγ receptor distribution on mannose receptor mediated phagocytosis

Universität Rostock, 2010

Abstract: In this study the recognition maps obtained by the simultaneous topography and recognition (TREC) imaging revealed that Fcγ receptors are distributed in micro-domains of sizes 4nm to 200nm. The fluorescent and electron-microscopy provided further evidence that these clusters are located within close proximity of mannose receptors. This pattern of distribution of FcγRs and MRs led to inhibition of the MR mediated mediated phagocytosis. The data presented in this thesis provide evidences of cross-talk between FcγR mediated and MR mediated phagocytosis.

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