Novel small molecules as GSK-3β inhibitors in human neural progenitor cells

Anne-Caroline Schmöle

doi:10.18453/rosdok_id00000792

Anne-Caroline Schmöle

Novel small molecules as GSK-3β inhibitors in human neural progenitor cells

Universität Rostock, 2010

https://doi.org/10.18453/rosdok_id00000792

Abstract: GSK-3β as the key enzyme of Wnt/β-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3β inhibitors. The influence on Wnt/β-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3β.

doctoral thesis free access

100%0 °

title:

Novel small molecules as GSK-3β inhibitors in human neural progenitor cells

contributing persons:

Anne-Caroline Schmöle[VerfasserIn]
	143723146
Arndt Rolfs , Prof. Dr.[AkademischeR BetreuerIn]
Matthias Beller , Prof. Dr.[AkademischeR BetreuerIn]
Sergei Kuznetsov , PD Dr.[AkademischeR BetreuerIn]
Johannes Schwarz , Prof. Dr.[AkademischeR BetreuerIn]

contributing corporate bodies:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

abstract:

GSK-3β as the key enzyme of Wnt/β-catenin pathway is involved in various processes during the neuronal differentiation of stem and progenitor cells. Therefore small molecules are of great interest as they might provide new pharmacological tools to influence and study underlying mechanism. Thus, we developed a multi-level screening system to identify novel GSK-3β inhibitors. The influence on Wnt/β-catenin signaling was evaluated in human neural progenitor cells. New compounds raised the neuronal differentiation, whereat it was shown that the effect was due antagonistic action at GSK-3β. [English]

document type:

doctoral thesis

institution:

Faculty of Mathematics and Natural Sciences

language:

English

subject class (DDC):

570 Life science

publication /
production:

Rostock

Rostock: Universität Rostock

2010