| title: |
| Annexin A1 as a new functional linker between actin filaments and phagosomes during
phagocytosis |
|
| contributing persons: |
| Devang Patel[VerfasserIn] |
 |
14332196X |
| Sergei A. Kuznetsov
, PD Dr.[AkademischeR BetreuerIn] |
| Gareth Griffiths
, Prof. Dr.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
In the current study annexin A1 was identified as a factor, which binds to latex beads
phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages
the association of endogenous annexin A1 with LBP membranes is strongly correlated
with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling
influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression
resulted in impaired phagocytosis and actin flashing. These data revealed that annexin
A1 as an important component of opsonic phagocytosis.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
|
| |
publication /
production: |
|
Rostock: Universität Rostock
|
|
2010
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000592 |
| created / modified: |
13.03.2012 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
access
viewer
fulltext