Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis

Devang Patel

doi:10.18453/rosdok_id00000797

Devang Patel

Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis

Universität Rostock, 2010

https://doi.org/10.18453/rosdok_id00000797

Abstract: In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis.

Dissertation Freier Zugang

Titel:

Annexin A1 as a new functional linker between actin filaments and phagosomes during phagocytosis

Beteiligte Personen:

Devang Patel[VerfasserIn]
	14332196X
Sergei A. Kuznetsov , PD Dr.[AkademischeR BetreuerIn]
Gareth Griffiths , Prof. Dr.[AkademischeR BetreuerIn]

Beteiligte Körperschaften:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

Zusammenfassung:

In the current study annexin A1 was identified as a factor, which binds to latex beads phagosomes (LBP) and facilitates F-actin-LBP interaction in vitro. In macrophages the association of endogenous annexin A1 with LBP membranes is strongly correlated with F-actin accumulation at the LBP. Furthermore, it showed that receptor signalling influenced annexin A1 recruitment on different LBP. Reduction of annexin A1 expression resulted in impaired phagocytosis and actin flashing. These data revealed that annexin A1 as an important component of opsonic phagocytosis. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Mathematisch-Naturwissenschaftliche Fakultät

Sprache:

Englisch

Sachgruppe der DNB:

570 Biowissenschaften, Biologie

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2010