| title: |
| Positive stranded RNA viruses: Dissecting the capsid of Hepatitis E and Chikungunya
viruses |
|
| contributing persons: |
| Saijo Thomas[VerfasserIn] |
 |
143547151 |
| Stephan Schaefer
, Prof. Dr. med.[AkademischeR BetreuerIn] |
| Hubert Bahl
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Capsid protein of two positive stranded RNA viruses, Hepatitis E virus (HEV) and Chikungunya
virus (ChikV), were investigated. HEV was detected in swine serum collected in Germany.
An infectious system for HEV was established and was used to check its egress. The
requirement of various amino acid sequences for the autoproteolytic cleavage of ChikV
capsid protease was investigated. I was also able to show that ChikV capsid is recognized
by karyopherins and its export is mediated by CRM1 dependent nuclear export signal.
[English] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 610 Medical sciences Medicine |
| 570 Life science |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2010
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000597 |
| created / modified: |
13.03.2012 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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