| title: |
| Polymer mediated gene delivery for adult stem cell therapy |
|
| other title: |
| Polymervermittelter Gentransfer für die Therapie mit adulten Stammzellen
[translated]
|
|
| contributing persons: |
| Weiwei Wang[VerfasserIn] |
 |
1011739771 |
| Gustav Steinhoff
, Prof. Dr. med.[AkademischeR BetreuerIn] |
| Dieter G. Weiss
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
| Doris Klee
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Polymer mediated gene delivery was studied and utilized in adult stem cell therapy.
The gene expression of human mesenchymal stem cells (MSCs) could be significantly
enhanced by polyethylenimine (PEI) mediated gene delivery. The tumor cell growth could
be effectively inhibited both in vitro and in vivo by delivering antisense oligonucleotide
with non-viral method. Furthermore, gene activated substrate (GAS) prepared in this
study could allow localized gene delivery, sustained gene release, high transfection
efficiency, low cytotoxicity and high potential for stem cell recruitment.
[German] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 610 Medical sciences Medicine |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2010
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000000643 |
| created / modified: |
13.05.2011 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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