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Martha Holtfreter

Schistosoma mansoni Sambon, 1907 (Plathelminthes, Digenea) : Entwicklung neuer therapeutischer und diagnostischer Ansätze

Universität Rostock, 2010

Abstract: Intestinal schistosomiasis is a parasitic disease in tropical and sub-tropical regions. The present work investigated the schistosomicidal potential of a “drug targeting” model and of the antimalarials mefloquine and primaquine. Additionally, the suitability of confocal laser scanning microscopy (CLSM) as a diagnostic tool was evaluated. A dose and time dependent schistosomicidal effect of albumin- and polyethylenglycol-conjugates and the antimalarials was demonstrated in vitro. CLSM visualises schistosomal eggs directly within gut tissue and permits determination of egg viability.

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