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Orianne Mazemondet

Spatio-temporal Dynamics of the Wnt/beta-catenin Signaling Pathway : A Computational Systems Biology Approach

Universität Rostock, 2011

Abstract: The Wnt/β-catenin signaling pathway is involved in human neural progenitor cell differentiation. This dissertation employs the cyclic workflow of computational systems biology to investigate the pathway spatio-temporal dynamics during differentiation. Quantitative in vitro analyses show biphasic kinetics of the pathway proteins. A computational model is developed to investigate in silico these kinetics in correlation with cell cycle and self-induced signaling. We show the importance of stochastic approach and suggest further experiments, hence closing the computational systems biology loop.

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