Synthesis of Functionalized Quinolines, Flavones, Coumarins, Naphthoates and Phthalates by Site-Selective Suzuki-Miyaura Cross-Coupling Reactions

Nadi Fakhry Eleya

doi:10.18453/rosdok_id00001028

Nadi Fakhry Eleya

Synthesis of Functionalized Quinolines, Flavones, Coumarins, Naphthoates and Phthalates by Site-Selective Suzuki-Miyaura Cross-Coupling Reactions

Universität Rostock, 2012

https://doi.org/10.18453/rosdok_id00001028

Abstract: This thesis includes regioselective palladium(0)-catalyzed Suzuki cross-coupling reactions of quinolines, flavones, coumarins, naphthaoates and phthalates. Suzuki cross-coupling reaction of 5,7-dibromo-8-(trifluoromethanesulfonyloxy)quinoline afforded arylated quinolines.The Suzuki reaction of the bis(triflates)of 5,7-dihydroxyflavone,4-methyl-5,7-dihydroxycoumarin,4-methyl-5,8-dihydroxycoumarin, ethyl 3,5-dihydroxy-2-naphthaoate and methyl 3,7-dihydroxy-2-naphthoate gave the corresponding arylated derivatives. The reaction of tetrabromophthalate with boronic acids gave tetraarylphthalates.

doctoral thesis free access

title:

Synthesis of Functionalized Quinolines, Flavones, Coumarins, Naphthoates and Phthalates by Site-Selective Suzuki-Miyaura Cross-Coupling Reactions

contributing persons:

Nadi Fakhry Eleya[VerfasserIn]
	1025628063
Wolfgang Maison , Prof. Dr.[AkademischeR BetreuerIn]
Peter Langer , Prof. Dr.[AkademischeR BetreuerIn]

contributing corporate bodies:

Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution]
	2147083-2

abstract:

This thesis includes regioselective palladium(0)-catalyzed Suzuki cross-coupling reactions of quinolines, flavones, coumarins, naphthaoates and phthalates. Suzuki cross-coupling reaction of 5,7-dibromo-8-(trifluoromethanesulfonyloxy)quinoline afforded arylated quinolines.The Suzuki reaction of the bis(triflates)of 5,7-dihydroxyflavone,4-methyl-5,7-dihydroxycoumarin,4-methyl-5,8-dihydroxycoumarin, ethyl 3,5-dihydroxy-2-naphthaoate and methyl 3,7-dihydroxy-2-naphthoate gave the corresponding arylated derivatives. The reaction of tetrabromophthalate with boronic acids gave tetraarylphthalates. [English]

document type:

doctoral thesis

institution:

Faculty of Mathematics and Natural Sciences

language:

English

subject class (DDC):

540 Chemistry & allied sciences

publication /
production:

Rostock: Universität Rostock

2012

identifiers: