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Nadi Fakhry Eleya

Synthesis of Functionalized Quinolines, Flavones, Coumarins, Naphthoates and Phthalates by Site-Selective Suzuki-Miyaura Cross-Coupling Reactions

Universität Rostock, 2012

Abstract: This thesis includes regioselective palladium(0)-catalyzed Suzuki cross-coupling reactions of quinolines, flavones, coumarins, naphthaoates and phthalates. Suzuki cross-coupling reaction of 5,7-dibromo-8-(trifluoromethanesulfonyloxy)quinoline afforded arylated quinolines.The Suzuki reaction of the bis(triflates)of 5,7-dihydroxyflavone,4-methyl-5,7-dihydroxycoumarin,4-methyl-5,8-dihydroxycoumarin, ethyl 3,5-dihydroxy-2-naphthaoate and methyl 3,7-dihydroxy-2-naphthoate gave the corresponding arylated derivatives. The reaction of tetrabromophthalate with boronic acids gave tetraarylphthalates.

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