title: |
KCNQ channel opening as a powerful mechanism for vasodilation |
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contributing persons: |
Nadezda Zhuravleva[VerfasserIn] |
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1027084400 |
Rudolf Schubert
, Prof. Dr. med.[AkademischeR BetreuerIn] |
Maik Gollasch
, Prof. Dr. med. Dr. rer. nat.[AkademischeR BetreuerIn] |
Olaf Grisk
, Prof. Dr. med.[AkademischeR BetreuerIn] |
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contributing corporate bodies: |
Universität Rostock, Universitätsmedizin[Grad-verleihende Institution] |
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1029510660 |
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abstract: |
KCNQ channels were recently found in the vascular system. We have tested the hypothesis
that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary
arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4
and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced
by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive
model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation,
also in pathological hypertensive conditions.
[English] |
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document type: |
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institution: |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
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publication / production: |
Rostock
Rostock: Universität Rostock
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2011
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000000877 |
created / modified: |
29.10.2012 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |