KCNQ channel opening as a powerful mechanism for vasodilation

Nadezda Zhuravleva

doi:10.18453/rosdok_id00001056

Nadezda Zhuravleva

KCNQ channel opening as a powerful mechanism for vasodilation

Universität Rostock, 2011

https://doi.org/10.18453/rosdok_id00001056

Abstract: KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions.

Dissertation Freier Zugang

Titel:

KCNQ channel opening as a powerful mechanism for vasodilation

Beteiligte Personen:

Nadezda Zhuravleva[VerfasserIn]
	1027084400
Rudolf Schubert , Prof. Dr. med.[AkademischeR BetreuerIn]
Maik Gollasch , Prof. Dr. med. Dr. rer. nat.[AkademischeR BetreuerIn]
Olaf Grisk , Prof. Dr. med.[AkademischeR BetreuerIn]

Beteiligte Körperschaften:

Universität Rostock, Universitätsmedizin[Grad-verleihende Institution]
	1029510660

Zusammenfassung:

KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions. [Englisch]

Dokumenttyp:

Dissertation

Einrichtung:

Universitätsmedizin

Sprache:

Englisch

Sachgruppe der DNB:

610 Medizin, Gesundheit

Veröffentlichung /
Entstehung:

Rostock

Rostock: Universität Rostock

2011