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Peter James Morgan

Characterisation of calcium signalling and functional development in an immortalised human neural progenitor cell line

Universität Rostock, 2011


Abstract: The development of an immortalised hNPC line, ReNcell VM, was investigated in standard cell cultures and after transplantation on to hippocampal organotypical brain slice cultures. Whole cell patch clamp recordings and Calcium imaging were used to characterise the functional development during proliferation and differentiation. The findings of this study provide insights into the functional properties of hNPCs, and identify a new method by which their development might be controlled in culture.

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