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Juliane Pasold

Die Dysregulation des Wnt/ß-Catenin-Signalwegs während der Chondro- und Osteogenese ist mit der Entwicklung einer Arthrose und der parallelen Ausprägung einer Hyperostose beim STR/ort-Mausstamm assoziiert

Universität Rostock, 2012

Abstract: The Wnt/ß-catenin pathway regulates the embryonic skeletal development and the remodelling of the bone mass. In this context we wanted to know if a dysregulation of the signaling pathway 1) could be associated with osteoarthritis in STR/ort mice and 2) could be associated with the here newly characterized bone mass defect in these mice. For Sfrp1, an antagonist of the Wnt signaling pathway, we identified DNA sequence variations and a differential expression at the RNA- and protein level during cartilage and bone development. This results in an increased activation of the Wnt signaling pathway.

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