| title: |
| Patient-individual models of gliomas: Establishment, characterization and applications |
|
| contributing persons: |
| Christina Susanne Mullins[VerfasserIn] |
 |
1041262876 |
| Reinhard Schröder
, Prof. Dr.[AkademischeR BetreuerIn] |
|
143434314 |
|
Universität Rostock, Institut für Biowissenschaften, Abt. Genetik |
| Michael Linnebacher
, PD Dr.[AkademischeR BetreuerIn] |
|
1028873808 |
|
Universität Rostock, AG Molekulare Onkologie und Immuntherapie, Abt. allgemeine Chirurgie |
| Stefaan Van Gool
, Prof. Dr.[AkademischeR BetreuerIn] |
|
UZ Leuven, Laboratorium Klinische Immunologie |
|
| contributing corporate bodies: |
| Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
|
2147083-2 |
|
| |
| abstract: |
|
Glioblastomas are the most common and aggressive brain tumors. The aim was establishing
tumor models from individual patients (in vitro and in vivo). Modeling was successful
from fresh and of note also from vitally frozen patient tumors. The models were characterized
in direct comparison to the original tumors. Molecular features as mutations, amplifications
and epigenetic alterations were highly maintained. Extensive drug sensitivity screens
were performed. These well-defined patient individual models are ideal for establishment
of individualized therapies and even immunological strategies.
[English] |
|
Ziel dieser Arbeit über Glioblastome, der häufigsten und aggressivsten Form von Hirntumoren,
war die Etablierung von Patienten-individuellen Tumormodellen in vitro und in vivo.
Eine neue Technik zur vitalen Kryo-Asservierung konnte etabliert werden. Molekulare
Eigenschaften wie Mutationen, Amplifikationen und epigenetische Veränderungen waren
in den Modellen im Vergleich zu den Primärtumoren zumeist erhalten. Neuronaler Ursprung,
Malignität und Sensitivität auf Therapeutika wurden analysiert. Diese Modelle sind
hervorragender Ausgangspunkt zur Etablierung individualisierter Therapien.
[German] |
|
| document type: |
|
| institution: |
| Faculty of Mathematics and Natural Sciences |
|
| language: |
|
| subject class (DDC): |
| 610 Medical sciences Medicine |
| 570 Life science |
|
| |
publication /
production: |
Rostock
|
Rostock: Universität Rostock
|
|
2013
|
|
| |
| identifiers: |
|
| |
| access condition: |
|
| license/rights statement: |
all rights reserved
This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
|
|
| RosDok id: |
rosdok_disshab_0000001040 |
| created / modified: |
03.09.2013 / 08.08.2023
|
| metadata license: |
The metadata of this document was dedicated to the public domain
(CC0 1.0 Universal Public Domain Dedication). |
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