Universität Rostock, 2013
Abstract: The percutaneous coronary intervention with implantation of a stent is the preferred method for the treatment of cardiovascular diseases. The aim is the further development of drug-eluting stents that significantly reduce the rate of restenosis. In this work 17β-estradiol and genistein were examined for the effect on vascular cells and cultured blood vessels. At the cellular and tissue level 17β-estradiol provides no cardio protective properties. The local release of genistein can improve the vascular healing response. It represents an option in the development of new drug-eluting stents.
doctoral thesis free access