title: |
Expression of and immune responses to leukemia antigens in patients with hematological
malignancies |
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contributing persons: |
Rosaely Casalegno Garduño[VerfasserIn] |
|
1025918991 |
Michael Schmitt
, Prof. Dr. med.[AkademischeR BetreuerIn] |
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Universitätsklinikum Heidelberg, Zelluläre Immunotherapie, Medizinische Klinik V |
Reinhard Schröder
, Prof. Dr. rer. nat.[AkademischeR BetreuerIn] |
|
143434314 |
|
Universität Rostock, Institut für Biowissenschaften, Abt. Genetik |
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contributing corporate bodies: |
Universität Rostock, Mathematisch-Naturwissenschaftliche Fakultät[Grad-verleihende Institution] |
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2147083-2 |
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abstract: |
Leukemia cells are characterized by differentially expressed leukemia-associated antigens
(LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the
T cellular immune response to these LAAs correlated with the clinical outcome of patients
suffering from leukemia. We investigated the expression of WT1 and RHAMM at RNA level
using qPCR before and after treatment. We concluded that WT1 is a suitable marker
for MRD after allogeneic SCT and that a WT1-specific T cell response might contribute
to the maintenance of CR.
[English] |
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document type: |
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institution: |
Faculty of Mathematics and Natural Sciences |
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language: |
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subject class (DDC): |
610 Medical sciences Medicine |
570 Life science |
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publication / production: |
Rostock
Rostock: Universität Rostock
|
2013
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identifiers: |
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access condition: |
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license/rights statement: |
all rights reserved This work may only be used under the terms of the German Copyright Law (Urheberrechtsgesetz). |
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RosDok id: |
rosdok_disshab_0000001061 |
created / modified: |
01.11.2013 / 08.08.2023
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metadata license: |
The metadata of this document was dedicated to the public domain (CC0 1.0 Universal Public Domain Dedication). |